Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation

Shogo Watanabe, Eisuke Amiya, Masafumi Watanabe, Munenori Takata, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Yumiko Hosoya, Kohzo Nagata, Ryozo Nagai, Issei Komuro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The physiological role of vasomotion, rhythmic oscillations in vascular tone or diameter, and its underlying mechanisms are unknown. We investigated the characteristics of brachial artery vasomotion in patients with ischemic heart disease (IHD).

Methods: We performed a retrospective study of 37 patients with IHD. Endothelial function was assessed using flowmediated dilation (FMD), and power spectral analysis of brachial artery diameter oscillations during FMD was performed. Frequency-domain components were calculated by integrating the power spectrums in three frequency bands (in ms2) using the MemCalc (GMS, Tokyo, Japan): very-low frequency (VLF), 0.003-0.04 Hz; low frequency (LF), 0.04-0.15 Hz; and high frequency (HF), 0.15-0.4 Hz. Total spectral power (TP) was calculated as the sum of all frequency bands, and each spectral component was normalized against TP.

Results: Data revealed that HF/TP closely correlated with FMD (r =20.33, p = 0.04), whereas VLF/TP and LF/TP did not. We also explored the relationship between elevated C-reactive protein (CRP) levels and vasomotion. HF/TP was significantly increased in subjects with high CRP levels (CRP;>0.08 mg/dL) compared with subjects with low CRP levels (0.052±0.026 versus 0.035±0.022, p

Conclusion: The HF component of brachial artery diameter oscillation during FMD measurement correlated well with FMD and increased in the presence of elevated CRP levels in subjects with IHD.

Original languageEnglish
Article numbere110013
JournalPLoS One
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 9 2014
Externally publishedYes

Fingerprint

C-reactive protein
myocardial ischemia
C-Reactive Protein
Myocardial Ischemia
Dilatation
Arm
Brachial Artery
Frequency bands
arteries
oscillation
Tokyo
Protein C
Power spectrum
Spectrum analysis
Blood Vessels
Japan
Retrospective Studies
retrospective studies
blood vessels
spectral analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation. / Watanabe, Shogo; Amiya, Eisuke; Watanabe, Masafumi; Takata, Munenori; Ozeki, Atsuko; Watanabe, Aya; Kawarasaki, Shuichi; Nakao, Tomoko; Hosoya, Yumiko; Nagata, Kohzo; Nagai, Ryozo; Komuro, Issei.

In: PLoS One, Vol. 9, No. 10, e110013, 09.10.2014.

Research output: Contribution to journalArticle

Watanabe, S, Amiya, E, Watanabe, M, Takata, M, Ozeki, A, Watanabe, A, Kawarasaki, S, Nakao, T, Hosoya, Y, Nagata, K, Nagai, R & Komuro, I 2014, 'Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation', PLoS One, vol. 9, no. 10, e110013. https://doi.org/10.1371/journal.pone.0110013
Watanabe, Shogo ; Amiya, Eisuke ; Watanabe, Masafumi ; Takata, Munenori ; Ozeki, Atsuko ; Watanabe, Aya ; Kawarasaki, Shuichi ; Nakao, Tomoko ; Hosoya, Yumiko ; Nagata, Kohzo ; Nagai, Ryozo ; Komuro, Issei. / Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation. In: PLoS One. 2014 ; Vol. 9, No. 10.
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AU - Takata, Munenori

AU - Ozeki, Atsuko

AU - Watanabe, Aya

AU - Kawarasaki, Shuichi

AU - Nakao, Tomoko

AU - Hosoya, Yumiko

AU - Nagata, Kohzo

AU - Nagai, Ryozo

AU - Komuro, Issei

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