TY - JOUR
T1 - Elevated audiovisual temporal interaction in patients with migraine without aura
AU - Yang, Weiping
AU - Chu, Bingqian
AU - Yang, Jiajia
AU - Yu, Yinghua
AU - Wu, Jinglong
AU - Yu, Shengyuan
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI Grants (25249026, 25303013, 24686034, JW), JSPS and VINNOVA under The Japan-Sweden Research Cooperative Program Number 7401300030 (JW), a Grant-in-Aid for Strategic Research Promotion by Okayama University (JW), and the National Science Foundation of China (30970417,81171058, SY).
Publisher Copyright:
© 2014, Yang et al.; licensee Springer.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background: Photophobia and phonophobia are the most prominent symptoms in patients with migraine without aura. Hypersensitivity to visual stimuli can lead to greater hypersensitivity to auditory stimuli, which suggests that the interaction between visual and auditory stimuli may play an important role in the pathogenesis of migraine. However, audiovisual temporal interactions in migraine have not been well studied. Therefore, our aim was to examine auditory and visual interactions in migraine. Methods: In this study, visual, auditory, and audiovisual stimuli with different temporal intervals between the visual and auditory stimuli were randomly presented to the left or right hemispace. During this time, the participants were asked to respond promptly to target stimuli. We used cumulative distribution functions to analyze the response times as a measure of audiovisual integration. Results: Our results showed that audiovisual integration was significantly elevated in the migraineurs compared with the normal controls (p < 0.05); however, audiovisual suppression was weaker in the migraineurs compared with the normal controls (p < 0.05). Conclusions: Our findings further objectively support the notion that migraineurs without aura are hypersensitive to external visual and auditory stimuli. Our study offers a new quantitative and objective method to evaluate hypersensitivity to audio-visual stimuli in patients with migraine.
AB - Background: Photophobia and phonophobia are the most prominent symptoms in patients with migraine without aura. Hypersensitivity to visual stimuli can lead to greater hypersensitivity to auditory stimuli, which suggests that the interaction between visual and auditory stimuli may play an important role in the pathogenesis of migraine. However, audiovisual temporal interactions in migraine have not been well studied. Therefore, our aim was to examine auditory and visual interactions in migraine. Methods: In this study, visual, auditory, and audiovisual stimuli with different temporal intervals between the visual and auditory stimuli were randomly presented to the left or right hemispace. During this time, the participants were asked to respond promptly to target stimuli. We used cumulative distribution functions to analyze the response times as a measure of audiovisual integration. Results: Our results showed that audiovisual integration was significantly elevated in the migraineurs compared with the normal controls (p < 0.05); however, audiovisual suppression was weaker in the migraineurs compared with the normal controls (p < 0.05). Conclusions: Our findings further objectively support the notion that migraineurs without aura are hypersensitive to external visual and auditory stimuli. Our study offers a new quantitative and objective method to evaluate hypersensitivity to audio-visual stimuli in patients with migraine.
KW - Attention
KW - Audiovisual integration
KW - Hypersensitivity
KW - Migraine
KW - Race model
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U2 - 10.1186/1129-2377-15-44
DO - 10.1186/1129-2377-15-44
M3 - Article
C2 - 24961903
AN - SCOPUS:84937511586
SN - 1129-2369
VL - 15
SP - 1
EP - 10
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 1
M1 - 44
ER -