Electrophysiological study on sensory nerve activity from the submandibular salivary gland in rats

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To evaluate the role of afferent information from the salivary gland, we analyzed the neural activity of the sensory nerve innervating the submandibular gland in anesthetized rats. The sensory nerves running through the parasympathetic nerve supply responded to mechanical pressure applied to the surface of the main duct and the body of the gland, whilst those in the sympathetic nerve supply responded only to the body of the gland. The sensory nerves in the sympathetic and parasympathetic nerve routes responded to pressure in the duct system produced by a retrograde injection of saline into the main duct. The threshold pressure for production of afferent discharges was higher than the maximum secretory pressure evoked by electrical stimulation of the parasympathetic secretory nerve. The retrograde ductal injection of drugs related to the inflammatory process (capsaicin and bradykinin) evoked intense multi-unit discharges in the sensory nerves of both routes. The sensory nerve in the sympathetic route was responsive to ligation of the artery to the gland. These results suggest that sensory nerves in the sympathetic and parasympathetic routes mainly conduct noxious information, and that those in the sympathetic route are responsive to ischemia and may control blood flow of the gland.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalBrain Research
Volume1680
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Submandibular Gland
Salivary Glands
Pressure
Injections
Capsaicin
Bradykinin
Electric Stimulation
Ligation
Ischemia
Arteries
Pharmaceutical Preparations

Keywords

  • Neural activity
  • Rat
  • Secretory pressure
  • Sensory nerve
  • Submandibular gland

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Electrophysiological study on sensory nerve activity from the submandibular salivary gland in rats. / Matsuo, Ryuji; Kobashi, Motoi; Fujita, Masako.

In: Brain Research, Vol. 1680, 01.02.2018, p. 137-142.

Research output: Contribution to journalArticle

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