Electrophysiological analysis of chemosensitive neurons within the area postrema of the rat

A. Adachi, Motoi Kobashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The area postrema (AP) has proved to be a chemoreceptive trigger zone for the emetic response. Evidence indicating other functions of the AP especially in the rat has grown in abundance recently. The present study is an attempt to demonstrate chemosensitive neurons within the AP electrophysiologically. Two different techniques were employed for chemical stimulation of the AP neurons: (1) the floor of the exposed fourth ventricle was superfused with isotonic glucose solution, hypertonic or hypotonic Ringer solution, or LiCl Ringer solution; (2) these solutions were injected into the left carotid artery. To confirm vagal afferent influences on given AP neurons, single shock electrical stimulation was delivered to the cervical vagal trunks of both sides. Three types of chemosensitive neurons were identified: (1) glucose responsive neurons that may participate in the control of satiety, (2) sodium (osmotic pressure) responsive neurons that may contribute to salt preference or control of water balance, and (3) LiCl responsive neurons that may play a role in conditioned taste aversion. Some of these chemosensitive neurons were influenced by the vagal afferent inputs, suggesting a close relationship between chemoreceptor mechanisms of the AP and visceral afferents.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalProgress in Brain Research
Volume74
Publication statusPublished - 1988

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Area Postrema
Neurons
Visceral Afferents
Hypotonic Solutions
Chemical Stimulation
Emetics
Isotonic Solutions
Fourth Ventricle
Glucose
Osmotic Pressure
Carotid Arteries
Electric Stimulation
Shock
Salts
Sodium
Water

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Electrophysiological analysis of chemosensitive neurons within the area postrema of the rat. / Adachi, A.; Kobashi, Motoi.

In: Progress in Brain Research, Vol. 74, 1988, p. 77-83.

Research output: Contribution to journalArticle

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