ELECTRON MICROSCOPIC STUDY OF MUCOEPIDERMOID CARCINOMA IN THE PANCREAS

Yuji Ohtsuki, Tadashi Yoshino, Kiyoshi Takahashi, Hiroshi Sonobe, Katsuaki Kohno, Tadaatsu Akagi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An autopsy case of extremely rare mucoepidermoid carcinoma of the pancreas in a 58‐year‐old male was reported. The main tumor in the pancreatic tail associated with wide‐spreading metastases, was histologically composed of squamous cancer cell nests Intermingled with mucin‐containing cells, but not true glandular structures except for metastatic foci in the liver. Electron microscopic findings of the main tumor revealed roughly three kinds of cancer cells, namely undifferentiated cells, squamous cells, and squamous cells with mucin‐containing intracytoplasmic lumina, accompanied by variety of transitional forms. The mucin was similar to that of the intra‐or interlobular duct epithelium of pancreas in mucin stains. Immunohistochemically, positive immune reaction of the cancer cells was observed by anti‐keratin, ‐epithelial membrane antigen and ‐carcinoembryonic antigen sera. These findings suggested that the cancer cells originated from undifferentiated cells of pancreatic duct, which showed multipotency to differentiate predominantly into squamous cells, but also into mucin‐producing cells. ACTA PATHOL. JPN. 37:1175–1182, 1987.

Original languageEnglish
Pages (from-to)1175-1182
Number of pages8
JournalPathology International
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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