Abstract
The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.
| Original language | English |
|---|---|
| Pages (from-to) | 728-741 |
| Number of pages | 14 |
| Journal | QSAR and Combinatorial Science |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Aug 1 2005 |
| Externally published | Yes |
Keywords
- Carbocation
- Cation flow method
- Electrochemical synthesis
- Microflow system
- Paired electrolysis
ASJC Scopus subject areas
- Drug Discovery
- Computer Science Applications
- Organic Chemistry
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Cite this
Suga, S., Okajima, M., Fujiwara, K., & Yoshida, J. I. (2005). Electrochemical combinatorial organic syntheses using microflow systems. QSAR and Combinatorial Science, 24(6), 728-741. https://doi.org/10.1002/qsar.200440003