Electrochemical combinatorial organic syntheses using microflow systems

Seiji Suga, Masayuki Okajima, Kazuyuki Fujiwara, Jun Ichi Yoshida

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.

Original languageEnglish
Pages (from-to)728-741
Number of pages14
JournalQSAR and Combinatorial Science
Volume24
Issue number6
DOIs
Publication statusPublished - Aug 2005
Externally publishedYes

Fingerprint

Synthetic Chemistry Techniques
Nucleophiles
Cations
Carbon
Synthesis
Electrolysis
Positive ions
Concurrent
Temperature

Keywords

  • Carbocation
  • Cation flow method
  • Electrochemical synthesis
  • Microflow system
  • Paired electrolysis

ASJC Scopus subject areas

  • Discrete Mathematics and Combinatorics
  • Pharmacology

Cite this

Electrochemical combinatorial organic syntheses using microflow systems. / Suga, Seiji; Okajima, Masayuki; Fujiwara, Kazuyuki; Yoshida, Jun Ichi.

In: QSAR and Combinatorial Science, Vol. 24, No. 6, 08.2005, p. 728-741.

Research output: Contribution to journalArticle

Suga, Seiji ; Okajima, Masayuki ; Fujiwara, Kazuyuki ; Yoshida, Jun Ichi. / Electrochemical combinatorial organic syntheses using microflow systems. In: QSAR and Combinatorial Science. 2005 ; Vol. 24, No. 6. pp. 728-741.
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