Electrochemical combinatorial organic syntheses using microflow systems

Seiji Suga, Masayuki Okajima, Kazuyuki Fujiwara, Jun Ichi Yoshida

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.

Original languageEnglish
Pages (from-to)728-741
Number of pages14
JournalQSAR and Combinatorial Science
Issue number6
Publication statusPublished - Aug 1 2005
Externally publishedYes


  • Carbocation
  • Cation flow method
  • Electrochemical synthesis
  • Microflow system
  • Paired electrolysis

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry


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