Abstract
The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.
| Original language | English |
|---|---|
| Pages (from-to) | 728-741 |
| Number of pages | 14 |
| Journal | QSAR and Combinatorial Science |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Aug 2005 |
| Externally published | Yes |
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Keywords
- Carbocation
- Cation flow method
- Electrochemical synthesis
- Microflow system
- Paired electrolysis
ASJC Scopus subject areas
- Discrete Mathematics and Combinatorics
- Pharmacology
Cite this
Electrochemical combinatorial organic syntheses using microflow systems. / Suga, Seiji; Okajima, Masayuki; Fujiwara, Kazuyuki; Yoshida, Jun Ichi.
In: QSAR and Combinatorial Science, Vol. 24, No. 6, 08.2005, p. 728-741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrochemical combinatorial organic syntheses using microflow systems
AU - Suga, Seiji
AU - Okajima, Masayuki
AU - Fujiwara, Kazuyuki
AU - Yoshida, Jun Ichi
PY - 2005/8
Y1 - 2005/8
N2 - The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.
AB - The "cation flow" method, in which highly reactive carbocations are generated in the absence of nucleophiles by low temperature electrolysis and are allowed to react with carbon nucleophiles in the microflow system to achieve direct electrooxidative C-C bond formation, has been developed. As an extension of the cation flow method, an electrochemical paired microflow system that involves concurrent anodic generation of carbocations and cathodic generation of carbon nucleophiles followed by their reactions to achieve straightforward C-C bond formation has also been developed.
KW - Carbocation
KW - Cation flow method
KW - Electrochemical synthesis
KW - Microflow system
KW - Paired electrolysis
UR - http://www.scopus.com/inward/record.url?scp=23944510232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944510232&partnerID=8YFLogxK
U2 - 10.1002/qsar.200440003
DO - 10.1002/qsar.200440003
M3 - Article
AN - SCOPUS:23944510232
VL - 24
SP - 728
EP - 741
JO - Molecular Informatics
JF - Molecular Informatics
SN - 1868-1743
IS - 6
ER -