Electroauxiliary-assisted sequential introduction of two carbon nucleophiles on the same α-carbon of nitrogen: Application to the synthesis of spiro compounds

Seiji Suga, Mitsuru Watanabe, Jun ichi Yoshida

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

The sequential introduction of two carbon nucleophiles on the same α-carbon of nitrogen by using selective oxidative cleavage of two silyl groups as electroauxilialies has been accomplished. The combination of this expedient transformation and ring-closing metathesis enables reliable and straightforward syntheses of nitrogen-containing spiro compounds, such as cephalotaxine.

Original languageEnglish
Pages (from-to)14824-14825
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number50
DOIs
Publication statusPublished - Dec 18 2002
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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