Electro-oxidative kinetic resolution of sec-alcohols by using an optically active N-oxyl mediator

Manabu Kuroboshi, Hiroshi Yoshihisa, Mariana N. Cortona, Yusuke Kawakami, Zake Gao, Hideo Tanaka

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Electro-oxidative kinetic resolution of sec-alcohols mediated with a catalytic amount of an optically active N-oxyl was performed by use of a simple undivided cell under constant current conditions. The selectivity factor (S-value) increased remarkably when the reaction was performed at lower temperatures. The optically active N-oxyl was recovered and used repeatedly without any change in efficiency and selectivity.

Original languageEnglish
Pages (from-to)8131-8135
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number42
DOIs
Publication statusPublished - Oct 14 2000

Keywords

  • Alcohols
  • Electrochemistry
  • Kinetic resolution
  • Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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