Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein

Chihiro Yoshihara, Ayaka Fukao, Keita Ando, Yuichi Tashiro, Shusuke Taniuchi, Sumio Takahashi, Sakae Takeuchi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hair and feather pigmentation is mainly determined by the distribution of two kinds of melanin, eumelanin and pheomelanin, which produce brown to black and yellow to red colorations, respectively. The agouti signaling protein (ASIP) acts as an antagonist or an inverse agonist of the melanocortin 1 receptor (MC1R), a G protein-coupled receptor for α-melanocyte-stimulating hormone (α-MSH). This antagonism of the MC1R by ASIP on melanocytes initiates a switch of melanin synthesis from eumelanogenesis to pheomelanogenesis in mammals. In the present study, we isolated multiple ASIP mRNA variants generated by alternative splicing and promoters in chicken feather follicles. The mRNA variants showed a discrete tissue distribution. However, mRNAs were expressed predominantly in the feather pulp of follicles. Paralleling mRNA distribution, ASIP immunoreactivity was observed in feather pulp. Interestingly, ASIP was stained with pheomelanin but not eumelanin in pulp areas that face developing barbs. We suggest that the elaborate color pattern of individual feathers is formed in part by the antagonistic action of ASIP that is produced by multiple mRNA variants in chicken feather follicles.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalGeneral and Comparative Endocrinology
Volume175
Issue number3
DOIs
Publication statusPublished - Feb 1 2012

Fingerprint

Agouti Signaling Protein
Agouti
Feathers
feathers
Chickens
Color
chickens
color
Messenger RNA
Receptor, Melanocortin, Type 1
eumelanin
pulp
alpha-melanocyte-stimulating hormone
proteins
Melanins
melanin
melanocyte-stimulating hormone
Melanocyte-Stimulating Hormones
receptors
melanocytes

Keywords

  • ASIP
  • Chicken
  • Feathers
  • Melanocortin
  • Pigmentation

ASJC Scopus subject areas

  • Endocrinology

Cite this

Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein. / Yoshihara, Chihiro; Fukao, Ayaka; Ando, Keita; Tashiro, Yuichi; Taniuchi, Shusuke; Takahashi, Sumio; Takeuchi, Sakae.

In: General and Comparative Endocrinology, Vol. 175, No. 3, 01.02.2012, p. 495-499.

Research output: Contribution to journalArticle

Yoshihara, Chihiro ; Fukao, Ayaka ; Ando, Keita ; Tashiro, Yuichi ; Taniuchi, Shusuke ; Takahashi, Sumio ; Takeuchi, Sakae. / Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein. In: General and Comparative Endocrinology. 2012 ; Vol. 175, No. 3. pp. 495-499.
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