EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

Fumio Kataoka, Hiroshi Tsuda, Tokuzo Arao, Sadako Nishimura, Hideo Tanaka, Hiroyuki Nomura, Tatsuyuki Chiyoda, Akira Hirasawa, Tomoko Akahane, Hiroshi Nishio, Kazuto Nishio, Daisuke Aoki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Stromal components interact with cancer cells to promote growth and metastasis. The purpose of this study was to identify genes expressed in stroma, which could provide prognostic information in epithelial ovarian cancer (EOC). Seventy-four patients were included. We performed gene expression profiling and confirmed array data using RT-PCR and immunohistochemistry. By microarray analysis, 52 candidate genes associated with progression free survival (PFS) were identified (P < 0.005). Expression of the early growth response 1 (EGR1) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) genes was further analyzed. Array data were confirmed by RT-PCR and multivariate analysis demonstrated that both EGR1 and FOSB expression in cancer stroma, and EGR1 expression in cancer are independent prognostic factors in EOC. Immunohistochemically, EGR1 protein is localized in cancer cells and α-smooth muscle actin positive stromal fibroblasts. The EGR1 and FOSB expression in stromal cells and EGR1 expression in cancer cells are prognostic indicators in EOC.

Original languageEnglish
Pages (from-to)300-312
Number of pages13
JournalGenes Chromosomes and Cancer
Volume51
Issue number3
DOIs
Publication statusPublished - Mar 1 2012
Externally publishedYes

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Gene Expression
Growth
Neoplasms
Early Growth Response Protein 1
Therapeutics
Genes
Polymerase Chain Reaction
Gene Expression Profiling
Osteosarcoma
Microarray Analysis
Stromal Cells
Oncogenes
Disease-Free Survival
Smooth Muscle Myocytes
Ovarian epithelial cancer
Actins
Multivariate Analysis
Fibroblasts
Immunohistochemistry
Neoplasm Metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. / Kataoka, Fumio; Tsuda, Hiroshi; Arao, Tokuzo; Nishimura, Sadako; Tanaka, Hideo; Nomura, Hiroyuki; Chiyoda, Tatsuyuki; Hirasawa, Akira; Akahane, Tomoko; Nishio, Hiroshi; Nishio, Kazuto; Aoki, Daisuke.

In: Genes Chromosomes and Cancer, Vol. 51, No. 3, 01.03.2012, p. 300-312.

Research output: Contribution to journalArticle

Kataoka, F, Tsuda, H, Arao, T, Nishimura, S, Tanaka, H, Nomura, H, Chiyoda, T, Hirasawa, A, Akahane, T, Nishio, H, Nishio, K & Aoki, D 2012, 'EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy', Genes Chromosomes and Cancer, vol. 51, no. 3, pp. 300-312. https://doi.org/10.1002/gcc.21916
Kataoka, Fumio ; Tsuda, Hiroshi ; Arao, Tokuzo ; Nishimura, Sadako ; Tanaka, Hideo ; Nomura, Hiroyuki ; Chiyoda, Tatsuyuki ; Hirasawa, Akira ; Akahane, Tomoko ; Nishio, Hiroshi ; Nishio, Kazuto ; Aoki, Daisuke. / EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. In: Genes Chromosomes and Cancer. 2012 ; Vol. 51, No. 3. pp. 300-312.
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