Efficient and practical synthesis of N-acetyl enamides from ketoximes by unique iron catalytic system

Takahiro Kunishige, Daisuke Sawada

Research output: Contribution to journalArticle

Abstract

A new procedure for the iron-catalyzed synthesis of enamides from ketoximes was developed, and its mechanism was proposed. A unique reduction system, with the concerted use of KI and Na2S2O4, was involved. The reaction exhibited a wide substrate scope and gave good yields in a short reaction time. The procedure is operationally simple and also applicable for the large-scale synthesis.

Original languageEnglish
Pages (from-to)1562-1565
Number of pages4
JournalTetrahedron Letters
Volume60
Issue number24
DOIs
Publication statusPublished - Jun 13 2019

Keywords

  • Enamide synthesis
  • Iron catalyst
  • Ketoxime
  • One-electron reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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