Efficacy of traction-assisted colorectal endoscopic submucosal dissection using a clip-and-thread technique: A prospective randomized study

Yasushi Yamasaki, Yoji Takeuchi, Noriya Uedo, Takashi Kanesaka, Minoru Kato, Kenta Hamada, Yusuke Tonai, Noriko Matsuura, Tomofumi Akasaka, Noboru Hanaoka, Koji Higashino, Ryu Ishihara, Hiroyuki Okada, Hiroyasu Iishi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background and Aim: Colorectal endoscopic submucosal dissection (ESD) remains challenging because of technical difficulties, long procedure time, and high risk of adverse events. To facilitate colorectal ESD, we developed traction-assisted colorectal ESD using a clip and thread (TAC-ESD) and conducted a randomized controlled trial to evaluate its efficacy. Methods: Patients with superficial colorectal neoplasms (SCN) ≥20 mm were enrolled and randomly assigned to the conventional-ESD group or to the TAC-ESD group. SCN ≤50 mm were treated by two intermediates, and SCN >50 mm were treated by two experts. Primary endpoint was procedure time. Secondary endpoints were TAC-ESD success rate (sustained application of the clip and thread until the end of the procedure), self-completion rate by the intermediates, and adverse events. Results: Altogether, 42 SCN were analyzed in each ESD group (conventional and TAC). Procedure time (median [range]) for the TAC-ESD group was significantly shorter than that for the conventional-ESD group (40 [11–86] min vs 70 [30–180] min, respectively; P < 0.0001). Success rate of TAC-ESD was 95% (40/42). The intermediates’ self-completion rate was significantly higher for the TAC-ESD group than for the conventional-ESD group (100% [39/39] vs 90% [36/40], respectively; P = 0.04). Adverse events included one intraoperative perforation in the conventional-ESD group and one delayed perforation in the TAC-ESD group. Conclusion: Traction-assisted colorectal endoscopic submucosal dissection reduced the procedure time and increased the self-completion rate by the intermediates (UMIN000018612).

Original languageEnglish
Pages (from-to)467-476
Number of pages10
JournalDigestive Endoscopy
Volume30
Issue number4
DOIs
Publication statusPublished - Jul 1 2018

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Traction
Surgical Instruments
Prospective Studies
Colorectal Neoplasms
Endoscopic Mucosal Resection

Keywords

  • clip and thread
  • colorectal neoplasm
  • endoscopic submucosal dissection
  • procedure time
  • traction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Efficacy of traction-assisted colorectal endoscopic submucosal dissection using a clip-and-thread technique : A prospective randomized study. / Yamasaki, Yasushi; Takeuchi, Yoji; Uedo, Noriya; Kanesaka, Takashi; Kato, Minoru; Hamada, Kenta; Tonai, Yusuke; Matsuura, Noriko; Akasaka, Tomofumi; Hanaoka, Noboru; Higashino, Koji; Ishihara, Ryu; Okada, Hiroyuki; Iishi, Hiroyasu.

In: Digestive Endoscopy, Vol. 30, No. 4, 01.07.2018, p. 467-476.

Research output: Contribution to journalArticle

Yamasaki, Y, Takeuchi, Y, Uedo, N, Kanesaka, T, Kato, M, Hamada, K, Tonai, Y, Matsuura, N, Akasaka, T, Hanaoka, N, Higashino, K, Ishihara, R, Okada, H & Iishi, H 2018, 'Efficacy of traction-assisted colorectal endoscopic submucosal dissection using a clip-and-thread technique: A prospective randomized study', Digestive Endoscopy, vol. 30, no. 4, pp. 467-476. https://doi.org/10.1111/den.13036
Yamasaki, Yasushi ; Takeuchi, Yoji ; Uedo, Noriya ; Kanesaka, Takashi ; Kato, Minoru ; Hamada, Kenta ; Tonai, Yusuke ; Matsuura, Noriko ; Akasaka, Tomofumi ; Hanaoka, Noboru ; Higashino, Koji ; Ishihara, Ryu ; Okada, Hiroyuki ; Iishi, Hiroyasu. / Efficacy of traction-assisted colorectal endoscopic submucosal dissection using a clip-and-thread technique : A prospective randomized study. In: Digestive Endoscopy. 2018 ; Vol. 30, No. 4. pp. 467-476.
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AU - Yamasaki, Yasushi

AU - Takeuchi, Yoji

AU - Uedo, Noriya

AU - Kanesaka, Takashi

AU - Kato, Minoru

AU - Hamada, Kenta

AU - Tonai, Yusuke

AU - Matsuura, Noriko

AU - Akasaka, Tomofumi

AU - Hanaoka, Noboru

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AU - Ishihara, Ryu

AU - Okada, Hiroyuki

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N2 - Background and Aim: Colorectal endoscopic submucosal dissection (ESD) remains challenging because of technical difficulties, long procedure time, and high risk of adverse events. To facilitate colorectal ESD, we developed traction-assisted colorectal ESD using a clip and thread (TAC-ESD) and conducted a randomized controlled trial to evaluate its efficacy. Methods: Patients with superficial colorectal neoplasms (SCN) ≥20 mm were enrolled and randomly assigned to the conventional-ESD group or to the TAC-ESD group. SCN ≤50 mm were treated by two intermediates, and SCN >50 mm were treated by two experts. Primary endpoint was procedure time. Secondary endpoints were TAC-ESD success rate (sustained application of the clip and thread until the end of the procedure), self-completion rate by the intermediates, and adverse events. Results: Altogether, 42 SCN were analyzed in each ESD group (conventional and TAC). Procedure time (median [range]) for the TAC-ESD group was significantly shorter than that for the conventional-ESD group (40 [11–86] min vs 70 [30–180] min, respectively; P < 0.0001). Success rate of TAC-ESD was 95% (40/42). The intermediates’ self-completion rate was significantly higher for the TAC-ESD group than for the conventional-ESD group (100% [39/39] vs 90% [36/40], respectively; P = 0.04). Adverse events included one intraoperative perforation in the conventional-ESD group and one delayed perforation in the TAC-ESD group. Conclusion: Traction-assisted colorectal endoscopic submucosal dissection reduced the procedure time and increased the self-completion rate by the intermediates (UMIN000018612).

AB - Background and Aim: Colorectal endoscopic submucosal dissection (ESD) remains challenging because of technical difficulties, long procedure time, and high risk of adverse events. To facilitate colorectal ESD, we developed traction-assisted colorectal ESD using a clip and thread (TAC-ESD) and conducted a randomized controlled trial to evaluate its efficacy. Methods: Patients with superficial colorectal neoplasms (SCN) ≥20 mm were enrolled and randomly assigned to the conventional-ESD group or to the TAC-ESD group. SCN ≤50 mm were treated by two intermediates, and SCN >50 mm were treated by two experts. Primary endpoint was procedure time. Secondary endpoints were TAC-ESD success rate (sustained application of the clip and thread until the end of the procedure), self-completion rate by the intermediates, and adverse events. Results: Altogether, 42 SCN were analyzed in each ESD group (conventional and TAC). Procedure time (median [range]) for the TAC-ESD group was significantly shorter than that for the conventional-ESD group (40 [11–86] min vs 70 [30–180] min, respectively; P < 0.0001). Success rate of TAC-ESD was 95% (40/42). The intermediates’ self-completion rate was significantly higher for the TAC-ESD group than for the conventional-ESD group (100% [39/39] vs 90% [36/40], respectively; P = 0.04). Adverse events included one intraoperative perforation in the conventional-ESD group and one delayed perforation in the TAC-ESD group. Conclusion: Traction-assisted colorectal endoscopic submucosal dissection reduced the procedure time and increased the self-completion rate by the intermediates (UMIN000018612).

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