Efficacy of mefloquine treatment and genetic profiles in uncomplicated plasmodium falciparum malaria in southern Lao PDR

Hiromu Toma, Toshimitsu Hatabu, Viengxay Vanisaveth, M. Kaiissar Mannoor, Hisami Watanabe, Changchun Li, Jun Kobayashi, Samlane Phompida, Shigeyuki Kano, Yoshiya Sato

Research output: Contribution to journalArticle

Abstract

We conducted a 28-day follow-up of 17 Laotian patients diagnosed with uncomplicated Plasmodium falciparum malaria treated with mefloquine (Mephaquine ®, MQ) alone to determine the efficacy. All patients were completely cured with MQ, without reappearance of asexual stage parasitemia at follow-up. Of the 7 isolates tested for genotypic analysis, one isolate was a Y86 mutant type of the pfmdr1 gene, the others were N86 wild. These findings suggest no MQ resistance in the study area possibly because the drug is rarely used in southern Lao PDR.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume42
Issue number4
Publication statusPublished - Jul 1 2011
Externally publishedYes

Keywords

  • Genetic profile
  • Lao PDR
  • Mefloquine
  • Plasmodium falciparum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Toma, H., Hatabu, T., Vanisaveth, V., Mannoor, M. K., Watanabe, H., Li, C., Kobayashi, J., Phompida, S., Kano, S., & Sato, Y. (2011). Efficacy of mefloquine treatment and genetic profiles in uncomplicated plasmodium falciparum malaria in southern Lao PDR. Southeast Asian Journal of Tropical Medicine and Public Health, 42(4), 759-763.