Efficacy of mandibular 2-implant overdenture: An updated meta-analysis on patient-based outcomes

Naoki Kodama, B. P. Singh, D. Cerutti-Kopplin, J. Feine, E. Emami

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The extent of heterogeneity regarding the efficacy of the mandibular 2-implant overdenture is still in question. The aim of this meta-analysis is to provide an update on the existing evidence from randomized controlled trials assessing the efficacy of the mandibular 2-implant overdenture in regard to patient-based outcomes. Electronic searches were carried out to September 2015 through MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Systematic Reviews. Only randomized controlled trials that compared conventional dentures with mandibular 2-implant overdentures were included. Patient-based outcomes were assessed, including patient satisfaction and oral health- and general health-related quality of life. Random effects models were used to pool the effect sizes of all included studies. Further stratified analyses and heterogeneity analyses were tested, as was publication bias. In addition to the 7 randomized controlled trials that were included in the previous meta-analysis, 4 new trials were identified and included in this update. A random effects model showed that, when compared with conventional dentures, mandibular 2-implant overdentures significantly improved patient satisfaction (pooled effect size = 0.87, z = 5.31, 95% confidence interval: 0.55 to 1.19, P < 0.0001, χ2 = 41.82, df = 8, P <0.0001, I2 = 81%) and oral health-related quality of life (pooled effect size = -0.66, z = 2.72, 95% confidence interval: -1.13 to -0.18, P = 0.007, χ2 = 21.26, df = 4, P = 0.0003, I2 = 81%). The differences in participant recruitment and their pretreatment condition were important sources of heterogeneity among the studies. Only 1 study investigated the impact of mandibular implant overdentures on perceived general health, and it revealed no between-treatment differences. The 2-implant mandibular overdenture improves patient satisfaction and quality of life for the general edentate population. Health status, poor oral condition, and patient characteristics may effect patient-based outcomes and should be considered by clinicians in treatment planning. Knowledge Transfer Statement: This meta-analysis shows that mandibular 2-implant overdentures are significantly more satisfactory to the general edentate populations than new conventional dentures. The results also show that mandibular 2-implant overdentures provide significantly better oral health-related quality of life than do new conventional dentures. These results should be shared with edentate patients in planning their treatment.

Original languageEnglish
Pages (from-to)20-30
Number of pages11
JournalJDR Clinical and Translational Research
Volume1
Issue number1
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Overlay Denture
Meta-Analysis
Dentures
Oral Health
Patient Satisfaction
Quality of Life
Randomized Controlled Trials
Confidence Intervals
Publication Bias
MEDLINE
Population
Health Status
Therapeutics

Keywords

  • Oral health
  • Patient satisfaction
  • Prosthesis
  • Quality of life
  • Randomized controlled trial
  • Systematic reviews

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Efficacy of mandibular 2-implant overdenture : An updated meta-analysis on patient-based outcomes. / Kodama, Naoki; Singh, B. P.; Cerutti-Kopplin, D.; Feine, J.; Emami, E.

In: JDR Clinical and Translational Research, Vol. 1, No. 1, 01.04.2016, p. 20-30.

Research output: Contribution to journalReview article

Kodama, Naoki ; Singh, B. P. ; Cerutti-Kopplin, D. ; Feine, J. ; Emami, E. / Efficacy of mandibular 2-implant overdenture : An updated meta-analysis on patient-based outcomes. In: JDR Clinical and Translational Research. 2016 ; Vol. 1, No. 1. pp. 20-30.
@article{10bf374e84eb4217a0d3ad0062497561,
title = "Efficacy of mandibular 2-implant overdenture: An updated meta-analysis on patient-based outcomes",
abstract = "The extent of heterogeneity regarding the efficacy of the mandibular 2-implant overdenture is still in question. The aim of this meta-analysis is to provide an update on the existing evidence from randomized controlled trials assessing the efficacy of the mandibular 2-implant overdenture in regard to patient-based outcomes. Electronic searches were carried out to September 2015 through MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Systematic Reviews. Only randomized controlled trials that compared conventional dentures with mandibular 2-implant overdentures were included. Patient-based outcomes were assessed, including patient satisfaction and oral health- and general health-related quality of life. Random effects models were used to pool the effect sizes of all included studies. Further stratified analyses and heterogeneity analyses were tested, as was publication bias. In addition to the 7 randomized controlled trials that were included in the previous meta-analysis, 4 new trials were identified and included in this update. A random effects model showed that, when compared with conventional dentures, mandibular 2-implant overdentures significantly improved patient satisfaction (pooled effect size = 0.87, z = 5.31, 95{\%} confidence interval: 0.55 to 1.19, P < 0.0001, χ2 = 41.82, df = 8, P <0.0001, I2 = 81{\%}) and oral health-related quality of life (pooled effect size = -0.66, z = 2.72, 95{\%} confidence interval: -1.13 to -0.18, P = 0.007, χ2 = 21.26, df = 4, P = 0.0003, I2 = 81{\%}). The differences in participant recruitment and their pretreatment condition were important sources of heterogeneity among the studies. Only 1 study investigated the impact of mandibular implant overdentures on perceived general health, and it revealed no between-treatment differences. The 2-implant mandibular overdenture improves patient satisfaction and quality of life for the general edentate population. Health status, poor oral condition, and patient characteristics may effect patient-based outcomes and should be considered by clinicians in treatment planning. Knowledge Transfer Statement: This meta-analysis shows that mandibular 2-implant overdentures are significantly more satisfactory to the general edentate populations than new conventional dentures. The results also show that mandibular 2-implant overdentures provide significantly better oral health-related quality of life than do new conventional dentures. These results should be shared with edentate patients in planning their treatment.",
keywords = "Oral health, Patient satisfaction, Prosthesis, Quality of life, Randomized controlled trial, Systematic reviews",
author = "Naoki Kodama and Singh, {B. P.} and D. Cerutti-Kopplin and J. Feine and E. Emami",
year = "2016",
month = "4",
day = "1",
doi = "10.1177/2380084416630508",
language = "English",
volume = "1",
pages = "20--30",
journal = "JDR Clinical and Translational Research",
issn = "2380-0844",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Efficacy of mandibular 2-implant overdenture

T2 - An updated meta-analysis on patient-based outcomes

AU - Kodama, Naoki

AU - Singh, B. P.

AU - Cerutti-Kopplin, D.

AU - Feine, J.

AU - Emami, E.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The extent of heterogeneity regarding the efficacy of the mandibular 2-implant overdenture is still in question. The aim of this meta-analysis is to provide an update on the existing evidence from randomized controlled trials assessing the efficacy of the mandibular 2-implant overdenture in regard to patient-based outcomes. Electronic searches were carried out to September 2015 through MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Systematic Reviews. Only randomized controlled trials that compared conventional dentures with mandibular 2-implant overdentures were included. Patient-based outcomes were assessed, including patient satisfaction and oral health- and general health-related quality of life. Random effects models were used to pool the effect sizes of all included studies. Further stratified analyses and heterogeneity analyses were tested, as was publication bias. In addition to the 7 randomized controlled trials that were included in the previous meta-analysis, 4 new trials were identified and included in this update. A random effects model showed that, when compared with conventional dentures, mandibular 2-implant overdentures significantly improved patient satisfaction (pooled effect size = 0.87, z = 5.31, 95% confidence interval: 0.55 to 1.19, P < 0.0001, χ2 = 41.82, df = 8, P <0.0001, I2 = 81%) and oral health-related quality of life (pooled effect size = -0.66, z = 2.72, 95% confidence interval: -1.13 to -0.18, P = 0.007, χ2 = 21.26, df = 4, P = 0.0003, I2 = 81%). The differences in participant recruitment and their pretreatment condition were important sources of heterogeneity among the studies. Only 1 study investigated the impact of mandibular implant overdentures on perceived general health, and it revealed no between-treatment differences. The 2-implant mandibular overdenture improves patient satisfaction and quality of life for the general edentate population. Health status, poor oral condition, and patient characteristics may effect patient-based outcomes and should be considered by clinicians in treatment planning. Knowledge Transfer Statement: This meta-analysis shows that mandibular 2-implant overdentures are significantly more satisfactory to the general edentate populations than new conventional dentures. The results also show that mandibular 2-implant overdentures provide significantly better oral health-related quality of life than do new conventional dentures. These results should be shared with edentate patients in planning their treatment.

AB - The extent of heterogeneity regarding the efficacy of the mandibular 2-implant overdenture is still in question. The aim of this meta-analysis is to provide an update on the existing evidence from randomized controlled trials assessing the efficacy of the mandibular 2-implant overdenture in regard to patient-based outcomes. Electronic searches were carried out to September 2015 through MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Systematic Reviews. Only randomized controlled trials that compared conventional dentures with mandibular 2-implant overdentures were included. Patient-based outcomes were assessed, including patient satisfaction and oral health- and general health-related quality of life. Random effects models were used to pool the effect sizes of all included studies. Further stratified analyses and heterogeneity analyses were tested, as was publication bias. In addition to the 7 randomized controlled trials that were included in the previous meta-analysis, 4 new trials were identified and included in this update. A random effects model showed that, when compared with conventional dentures, mandibular 2-implant overdentures significantly improved patient satisfaction (pooled effect size = 0.87, z = 5.31, 95% confidence interval: 0.55 to 1.19, P < 0.0001, χ2 = 41.82, df = 8, P <0.0001, I2 = 81%) and oral health-related quality of life (pooled effect size = -0.66, z = 2.72, 95% confidence interval: -1.13 to -0.18, P = 0.007, χ2 = 21.26, df = 4, P = 0.0003, I2 = 81%). The differences in participant recruitment and their pretreatment condition were important sources of heterogeneity among the studies. Only 1 study investigated the impact of mandibular implant overdentures on perceived general health, and it revealed no between-treatment differences. The 2-implant mandibular overdenture improves patient satisfaction and quality of life for the general edentate population. Health status, poor oral condition, and patient characteristics may effect patient-based outcomes and should be considered by clinicians in treatment planning. Knowledge Transfer Statement: This meta-analysis shows that mandibular 2-implant overdentures are significantly more satisfactory to the general edentate populations than new conventional dentures. The results also show that mandibular 2-implant overdentures provide significantly better oral health-related quality of life than do new conventional dentures. These results should be shared with edentate patients in planning their treatment.

KW - Oral health

KW - Patient satisfaction

KW - Prosthesis

KW - Quality of life

KW - Randomized controlled trial

KW - Systematic reviews

UR - http://www.scopus.com/inward/record.url?scp=85017624214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017624214&partnerID=8YFLogxK

U2 - 10.1177/2380084416630508

DO - 10.1177/2380084416630508

M3 - Review article

AN - SCOPUS:85017624214

VL - 1

SP - 20

EP - 30

JO - JDR Clinical and Translational Research

JF - JDR Clinical and Translational Research

SN - 2380-0844

IS - 1

ER -