Efficacy of long-term azathioprine for relapsing nephrotic syndrome

Masahiro Hiraoka, Hirokazu Tsukahara, Chikahide Hori, Yusei Ohshima, Toru Momoi, Akihiko Seo, Mitsufumi Mayumi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Seven patients who had an initial attack of nephrotic syndrome in childhood and had frequent relapses even after cyclophosphamide therapy were given a 2-year course of azathioprine. The mean annual relapse rates decreased from 2.4 ± 0.5 in the year preceding azathioprine to 0.4 ± 0.8 in the 1st and 2nd years after its initiation. All six patients who were observed for more than 6 months after discontinuation of the therapy were relapse free for this period. Average doses of prednisolone could also be decreased in the 2nd and subsequent years after the therapy. There were no significant toxic effects. Long-term azathioprine therapy may be well tolerated and effective for nephrotic patients with frequent relapses.

Original languageEnglish
Pages (from-to)776-778
Number of pages3
JournalPediatric Nephrology
Volume14
Issue number8-9
Publication statusPublished - Aug 2000
Externally publishedYes

Fingerprint

Azathioprine
Nephrotic Syndrome
Recurrence
Poisons
Therapeutics
Prednisolone
Cyclophosphamide

Keywords

  • Azathioprine
  • Cyclophosphamide
  • Frequent relapses
  • Nephrotic syndrome (childhood)

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Hiraoka, M., Tsukahara, H., Hori, C., Ohshima, Y., Momoi, T., Seo, A., & Mayumi, M. (2000). Efficacy of long-term azathioprine for relapsing nephrotic syndrome. Pediatric Nephrology, 14(8-9), 776-778.

Efficacy of long-term azathioprine for relapsing nephrotic syndrome. / Hiraoka, Masahiro; Tsukahara, Hirokazu; Hori, Chikahide; Ohshima, Yusei; Momoi, Toru; Seo, Akihiko; Mayumi, Mitsufumi.

In: Pediatric Nephrology, Vol. 14, No. 8-9, 08.2000, p. 776-778.

Research output: Contribution to journalArticle

Hiraoka, M, Tsukahara, H, Hori, C, Ohshima, Y, Momoi, T, Seo, A & Mayumi, M 2000, 'Efficacy of long-term azathioprine for relapsing nephrotic syndrome', Pediatric Nephrology, vol. 14, no. 8-9, pp. 776-778.
Hiraoka M, Tsukahara H, Hori C, Ohshima Y, Momoi T, Seo A et al. Efficacy of long-term azathioprine for relapsing nephrotic syndrome. Pediatric Nephrology. 2000 Aug;14(8-9):776-778.
Hiraoka, Masahiro ; Tsukahara, Hirokazu ; Hori, Chikahide ; Ohshima, Yusei ; Momoi, Toru ; Seo, Akihiko ; Mayumi, Mitsufumi. / Efficacy of long-term azathioprine for relapsing nephrotic syndrome. In: Pediatric Nephrology. 2000 ; Vol. 14, No. 8-9. pp. 776-778.
@article{5e686f3ab05047958be4223a211f064b,
title = "Efficacy of long-term azathioprine for relapsing nephrotic syndrome",
abstract = "Seven patients who had an initial attack of nephrotic syndrome in childhood and had frequent relapses even after cyclophosphamide therapy were given a 2-year course of azathioprine. The mean annual relapse rates decreased from 2.4 ± 0.5 in the year preceding azathioprine to 0.4 ± 0.8 in the 1st and 2nd years after its initiation. All six patients who were observed for more than 6 months after discontinuation of the therapy were relapse free for this period. Average doses of prednisolone could also be decreased in the 2nd and subsequent years after the therapy. There were no significant toxic effects. Long-term azathioprine therapy may be well tolerated and effective for nephrotic patients with frequent relapses.",
keywords = "Azathioprine, Cyclophosphamide, Frequent relapses, Nephrotic syndrome (childhood)",
author = "Masahiro Hiraoka and Hirokazu Tsukahara and Chikahide Hori and Yusei Ohshima and Toru Momoi and Akihiko Seo and Mitsufumi Mayumi",
year = "2000",
month = "8",
language = "English",
volume = "14",
pages = "776--778",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer Verlag",
number = "8-9",

}

TY - JOUR

T1 - Efficacy of long-term azathioprine for relapsing nephrotic syndrome

AU - Hiraoka, Masahiro

AU - Tsukahara, Hirokazu

AU - Hori, Chikahide

AU - Ohshima, Yusei

AU - Momoi, Toru

AU - Seo, Akihiko

AU - Mayumi, Mitsufumi

PY - 2000/8

Y1 - 2000/8

N2 - Seven patients who had an initial attack of nephrotic syndrome in childhood and had frequent relapses even after cyclophosphamide therapy were given a 2-year course of azathioprine. The mean annual relapse rates decreased from 2.4 ± 0.5 in the year preceding azathioprine to 0.4 ± 0.8 in the 1st and 2nd years after its initiation. All six patients who were observed for more than 6 months after discontinuation of the therapy were relapse free for this period. Average doses of prednisolone could also be decreased in the 2nd and subsequent years after the therapy. There were no significant toxic effects. Long-term azathioprine therapy may be well tolerated and effective for nephrotic patients with frequent relapses.

AB - Seven patients who had an initial attack of nephrotic syndrome in childhood and had frequent relapses even after cyclophosphamide therapy were given a 2-year course of azathioprine. The mean annual relapse rates decreased from 2.4 ± 0.5 in the year preceding azathioprine to 0.4 ± 0.8 in the 1st and 2nd years after its initiation. All six patients who were observed for more than 6 months after discontinuation of the therapy were relapse free for this period. Average doses of prednisolone could also be decreased in the 2nd and subsequent years after the therapy. There were no significant toxic effects. Long-term azathioprine therapy may be well tolerated and effective for nephrotic patients with frequent relapses.

KW - Azathioprine

KW - Cyclophosphamide

KW - Frequent relapses

KW - Nephrotic syndrome (childhood)

UR - http://www.scopus.com/inward/record.url?scp=0033914268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033914268&partnerID=8YFLogxK

M3 - Article

C2 - 10955926

AN - SCOPUS:0033914268

VL - 14

SP - 776

EP - 778

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 8-9

ER -