Efficacy of fiber tractography in the stereotactic surgery of the thalamus for patients with essential tremor

Susumu Sasada, Takashi Agari, Tatsuya Sasaki, Akihiko Kondo, Aiko Shinko, Takaaki Wakamori, Mihoko Okazaki, Ittetsu Kin, Ken Kuwahara, Masahiro Kameda, Takao Yasuhara, Isao Date

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several targets and targeting methods are utilized in stereotactic surgery to achieve tremor suppression for patients with intractable tremor. Recent developments in magnetic resonance imaging, including diffusion tensor imaging, have enabled the setting of appropriate targets in stereotactic surgery. In this retrospective study, the optimal target to suppress tremors in stereotactic surgery was explored using diffusion tensor image-based fiber tractography. Four tracts were focused on in this study, namely: the cerebello-thalamopremotor cortical fiber tract, cerebello-thalamo-primary motor cortical fiber tract, spino-thalamo-somatosensory cortical fiber tract, and pyramidal tract. In 10 patients with essential tremor, we evaluated the thalamotomy lesions and active contacts of the lead in thalamic stimulation by diffusion tensor image-based fiber tractography to reveal which part of the cerebral cortex is most affected by stereotactic surgery. Tremor suppression and adverse events were also evaluated in the patients involved in this study. Consequently, the good tremor suppression was achieved in all patients. There had been no permanent adverse events 3 months after surgery. Twelve lesions in thalamotomy patients or active contacts of the lead in thalamic stimulation patients were on the cerebello-thalamo-premotor cortical fiber tract (12/14 lesions or active contacts: 86%). In conclusion, the cerebello-thalamo-premotor cortical fiber tract may be an optimal target for tremor suppression. Diffusion tensor image-based fiber tractography may enable us to both determine the optimal target to achieve strong tremor suppression and to reduce the number of adverse events by keeping lesions or electrodes away from important fiber tracts, such as the pyramidal tract and spinothalamic fibers.

Original languageEnglish
Pages (from-to)392-401
Number of pages10
JournalNeurologia Medico-Chirurgica
Volume57
Issue number8
DOIs
Publication statusPublished - 2017

Fingerprint

Essential Tremor
Tremor
Thalamus
Pyramidal Tracts
Diffusion Tensor Imaging
Cerebral Cortex
Electrodes
Retrospective Studies
Magnetic Resonance Imaging

Keywords

  • Diffusion tensor image
  • Essential tremor
  • Fiber tractography
  • Premotor cortex
  • Thalamus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Efficacy of fiber tractography in the stereotactic surgery of the thalamus for patients with essential tremor. / Sasada, Susumu; Agari, Takashi; Sasaki, Tatsuya; Kondo, Akihiko; Shinko, Aiko; Wakamori, Takaaki; Okazaki, Mihoko; Kin, Ittetsu; Kuwahara, Ken; Kameda, Masahiro; Yasuhara, Takao; Date, Isao.

In: Neurologia Medico-Chirurgica, Vol. 57, No. 8, 2017, p. 392-401.

Research output: Contribution to journalArticle

Sasada, Susumu ; Agari, Takashi ; Sasaki, Tatsuya ; Kondo, Akihiko ; Shinko, Aiko ; Wakamori, Takaaki ; Okazaki, Mihoko ; Kin, Ittetsu ; Kuwahara, Ken ; Kameda, Masahiro ; Yasuhara, Takao ; Date, Isao. / Efficacy of fiber tractography in the stereotactic surgery of the thalamus for patients with essential tremor. In: Neurologia Medico-Chirurgica. 2017 ; Vol. 57, No. 8. pp. 392-401.
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