Effects of zinc ion on type A monoamine oxidase in monkey brain mitochondria

Toru Egashira, Fusako Takayama, Kumiko Sakai

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of ZnSO4 on types A and B monoamine oxidase (MAO) isozymes in monkey brain mitochondria were investigated, in vitro. Type A MAO activity in monkey brain decreased to about 50% with 1μM ZnSO4 using serotonin as a substrate, and this inhibition was proportional to the concentration of ZnSO4. ZnSO4 had no effect, however, on type B MAO activity in monkey brain using β-phenylethylamine as a substrate. The inhibition by ZnSO4 of type A MAO activity was competitive and reversible. ZnSO4 did not inhibit either type A or type B MAO activity in rat brain mitochondria. Almost similar results were also obtained when ZnCl2 was used, in vitro. These results indicate that the inhibiting action of zinc ion differs depending on animal species and organ. Type A MAO in monkey brain mitochondria was highly sensitive to zinc ion, while type B activity was less sensitive.

Original languageEnglish
Pages (from-to)625-627
Number of pages3
JournalBiochemical Pharmacology
Volume65
Issue number4
DOIs
Publication statusPublished - Feb 15 2003

Keywords

  • Monkey brain
  • Rat brain
  • Type A MAO
  • Type A MAO inhibitor
  • Type B MAO
  • Zinc ion

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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