Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: The 'power rehabilitation' program

Shin Ichiro Murakami, Takemi Otsuki, Megumi Maeda, Yoshie Miura, Seiko Morii, Kenji Kiyokane, Shin Ichi Hayakawa, Atsushi Maeda, Takayo Imakawa, Shunpei Harada, Torataro Handa, Yasumitsu Nishimura, Shuko Murakami, Naoko Kumagai, Hiroaki Hayashi, Ying Chen, Shin Ichiro Suemori, Yumiko Fukushima, Seikoh Nishida, Keisuke Fukushima

Research output: Contribution to journalArticle

4 Citations (Scopus)


The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established as a rehabilitation program. To investigate the individual factors which influence the effects of 'Power Rehabilitation', single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene and the ciliary neurotrophic factor (CNTF) gene were analyzed, and the relationship between SNP patterns and the effects of 'Power Rehabilitation' was evaluated. 'Power Rehabilitation' had an effect on the physiological functions involved in the activities of daily life (ADL) rather than muscle strength and size. In addition, certain SNP patterns showed better improvement of parameters associated with the effects of 'Power Rehabilitation' as analyzed by comparison between SNP patterns and factor analysis. Large scale analyses are required to ensure this tendency and to discover individual factors which may help to promote the health and QOL of the aged population.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalInternational journal of molecular medicine
Issue number1
Publication statusPublished - Apr 23 2009
Externally publishedYes



  • Low-resistance training
  • Rehabilitation
  • Single nucleotide polymorphism
  • Vitmin D receptor

ASJC Scopus subject areas

  • Genetics

Cite this

Murakami, S. I., Otsuki, T., Maeda, M., Miura, Y., Morii, S., Kiyokane, K., Hayakawa, S. I., Maeda, A., Imakawa, T., Harada, S., Handa, T., Nishimura, Y., Murakami, S., Kumagai, N., Hayashi, H., Chen, Y., Suemori, S. I., Fukushima, Y., Nishida, S., & Fukushima, K. (2009). Effects of vitamin D receptor gene polymorphisms on low-resistance training using exercise machines: The 'power rehabilitation' program. International journal of molecular medicine, 23(1), 81-88. https://doi.org/10.3892/ijmm_00000104