TY - JOUR
T1 - Effects of vasopressin on histamine H1 receptor antagonist-induced spatial memory deficits in rats
AU - Taga, Chiyomi
AU - Sugimoto, Yukio
AU - Nishiga, Miyuki
AU - Fujii, Yoko
AU - Kamei, Chiaki
PY - 2001/7/6
Y1 - 2001/7/6
N2 - The effects of [Arg8] vasopressin on histamine H1 receptor antagonist-induced memory deficits were investigated using the eight-arm radial maze performance test in rats. Pyrilamine and diphenhydramine as well as scopolamine induced memory deficits characterized by increases in the number of total errors, reference memory errors and working memory errors. [Arg8] vasopressin improved not only scopolamine-but also pyrilamine-and diphenhydramine-induced memory deficits, although a high dose of [Arg8] vasopressin was needed to antagonize pyrilamine-induced memory deficits. The effects of pyrilamine on the brain [Arg8] vasopressin content were studied, and the hippocampus [Arg8] vasopressin content was shown to be decreased after pyrilamine injection. From these observations, it seems likely that [Arg8] vasopressin participates in not only the cholinergic system but also the histaminergic system in spatial memory.
AB - The effects of [Arg8] vasopressin on histamine H1 receptor antagonist-induced memory deficits were investigated using the eight-arm radial maze performance test in rats. Pyrilamine and diphenhydramine as well as scopolamine induced memory deficits characterized by increases in the number of total errors, reference memory errors and working memory errors. [Arg8] vasopressin improved not only scopolamine-but also pyrilamine-and diphenhydramine-induced memory deficits, although a high dose of [Arg8] vasopressin was needed to antagonize pyrilamine-induced memory deficits. The effects of pyrilamine on the brain [Arg8] vasopressin content were studied, and the hippocampus [Arg8] vasopressin content was shown to be decreased after pyrilamine injection. From these observations, it seems likely that [Arg8] vasopressin participates in not only the cholinergic system but also the histaminergic system in spatial memory.
KW - Histamine H receptor antagonist
KW - Reference memory
KW - Working memory
KW - [Arg] vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0035816438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035816438&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(01)01080-9
DO - 10.1016/S0014-2999(01)01080-9
M3 - Article
C2 - 11448481
AN - SCOPUS:0035816438
VL - 423
SP - 167
EP - 170
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -