Effects of vasopressin on histamine H1 receptor antagonist-induced spatial memory deficits in rats

Chiyomi Taga, Yukio Sugimoto, Miyuki Nishiga, Yoko Fujii, Chiaki Kamei

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The effects of [Arg8] vasopressin on histamine H1 receptor antagonist-induced memory deficits were investigated using the eight-arm radial maze performance test in rats. Pyrilamine and diphenhydramine as well as scopolamine induced memory deficits characterized by increases in the number of total errors, reference memory errors and working memory errors. [Arg8] vasopressin improved not only scopolamine-but also pyrilamine-and diphenhydramine-induced memory deficits, although a high dose of [Arg8] vasopressin was needed to antagonize pyrilamine-induced memory deficits. The effects of pyrilamine on the brain [Arg8] vasopressin content were studied, and the hippocampus [Arg8] vasopressin content was shown to be decreased after pyrilamine injection. From these observations, it seems likely that [Arg8] vasopressin participates in not only the cholinergic system but also the histaminergic system in spatial memory.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalEuropean Journal of Pharmacology
Volume423
Issue number2-3
DOIs
Publication statusPublished - Jul 6 2001

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Histamine H1 Antagonists
Pyrilamine
Memory Disorders
Vasopressins
Diphenhydramine
Scopolamine Hydrobromide
Short-Term Memory
Cholinergic Agents
Spatial Memory
Hippocampus
Injections
Brain

Keywords

  • [Arg] vasopressin
  • Histamine H receptor antagonist
  • Reference memory
  • Working memory

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of vasopressin on histamine H1 receptor antagonist-induced spatial memory deficits in rats. / Taga, Chiyomi; Sugimoto, Yukio; Nishiga, Miyuki; Fujii, Yoko; Kamei, Chiaki.

In: European Journal of Pharmacology, Vol. 423, No. 2-3, 06.07.2001, p. 167-170.

Research output: Contribution to journalArticle

Taga, Chiyomi ; Sugimoto, Yukio ; Nishiga, Miyuki ; Fujii, Yoko ; Kamei, Chiaki. / Effects of vasopressin on histamine H1 receptor antagonist-induced spatial memory deficits in rats. In: European Journal of Pharmacology. 2001 ; Vol. 423, No. 2-3. pp. 167-170.
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