Effects of vasopressin and involvement of receptor subtypes in the rat central amygdaloid nucleus in vitro

Yun Fei Lu, A. Moriwaki, K. Tomizawa, H. Onuma, X. H. Cai, H. Matsui

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18 Citations (Scopus)


Effects of arginine-vasopressin (AVP) on neurons in the central amygdaloid nucleus (ACe) were investigated with rat brain slice preparations using extracellular recording methods. Of 160 ACe neurons tested, 70 cells (44%) were excited and 9 cells (6%) were inhibited by bath application of AVP at 3 X 10-7 M. The excitatory effects of AVP were dose-dependent and the threshold concentration was approximately 10-10 to 10-9 M. The excitatory effects of AVP persisted under blockade of synaptic transmission by perfusing with Ca2+-free and high-Mg2+ medium, whereas the inhibitory effects were abolished by synaptic blockade. AVP-induced effects were mimicked by a V1-receptor agonist and completely blocked by a selective V1- antagonist. V2-agonist produced no effects on ACe neurons and V2-antagonist had no effect on AVP-induced excitation. These results showed that the excitatory effect of AVP on ACe neurons was produced by a direct action through the V1-receptors, whereas the inhibitory response of ACe neurons to AVP seemed to be produced by an indirect action. The results of this study suggest that AVP is involved in the amygdala-relevant functions as a neurotransmitter or a neuromodulator.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalBrain Research
Issue number1-2
Publication statusPublished - Sep 12 1997


  • Amygdala
  • Brain slice
  • Central amygdaloid nucleus
  • Neuron activity
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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