TY - JOUR
T1 - Effects of various N-terminal fragments of glucagon-like peptide-1(7- 36) on food intake in the neonatal chick
AU - Furuse, Mitsuhiro
AU - Bungo, Takashi
AU - Shimojo, Masataka
AU - Masuda, Yasuhisa
AU - Saito, Noboru
AU - Hasegawa, Shin
AU - Sugahara, Kunio
N1 - Funding Information:
This study was supported by grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan and by Kyowa Hakko Kogyo, Tokyo, Japan.
PY - 1998/10/5
Y1 - 1998/10/5
N2 - Recently, the suppressive effect on food intake by the central administration of glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the central nervous system was suggested, though the role for C-terminal amino acids in the central nervous system has not been reported. The present study was done to elucidate the central effect of N-terminal fragments of GLP-1(7-36) on food intake of the neonatal chick. Intracerebroventricular (i.c.v.) administration of mammalian GLP-1(7-36) inhibited food intake of chicks, but the fragments of GLP-1(7-16) and GLP- 1(7-26) did not show the suppressive effect on food intake. Furthermore, the extended fragments, GLP-1(7-30) and GLP-1(7-33), also had no effects on food intake. It is concluded that C-terminal amino acids of GLP-1(7-36) have an important role for the bioactivity in the central nervous system with special reference to feeding behavior.
AB - Recently, the suppressive effect on food intake by the central administration of glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the central nervous system was suggested, though the role for C-terminal amino acids in the central nervous system has not been reported. The present study was done to elucidate the central effect of N-terminal fragments of GLP-1(7-36) on food intake of the neonatal chick. Intracerebroventricular (i.c.v.) administration of mammalian GLP-1(7-36) inhibited food intake of chicks, but the fragments of GLP-1(7-16) and GLP- 1(7-26) did not show the suppressive effect on food intake. Furthermore, the extended fragments, GLP-1(7-30) and GLP-1(7-33), also had no effects on food intake. It is concluded that C-terminal amino acids of GLP-1(7-36) have an important role for the bioactivity in the central nervous system with special reference to feeding behavior.
KW - Central
KW - Chicken
KW - Feeding behavior
KW - Fragment
KW - Glucagon-like peptide-1 (GLP-1)
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U2 - 10.1016/S0006-8993(98)00798-7
DO - 10.1016/S0006-8993(98)00798-7
M3 - Article
C2 - 9757042
AN - SCOPUS:0032487629
SN - 0006-8993
VL - 807
SP - 214
EP - 217
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -