Effects of various N-terminal fragments of glucagon-like peptide-1(7- 36) on food intake in the neonatal chick

Mitsuhiro Furuse, Takashi Bungo, Masataka Shimojo, Yasuhisa Masuda, Noboru Saito, Shin Hasegawa, Kunio Sugahara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recently, the suppressive effect on food intake by the central administration of glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the central nervous system was suggested, though the role for C-terminal amino acids in the central nervous system has not been reported. The present study was done to elucidate the central effect of N-terminal fragments of GLP-1(7-36) on food intake of the neonatal chick. Intracerebroventricular (i.c.v.) administration of mammalian GLP-1(7-36) inhibited food intake of chicks, but the fragments of GLP-1(7-16) and GLP- 1(7-26) did not show the suppressive effect on food intake. Furthermore, the extended fragments, GLP-1(7-30) and GLP-1(7-33), also had no effects on food intake. It is concluded that C-terminal amino acids of GLP-1(7-36) have an important role for the bioactivity in the central nervous system with special reference to feeding behavior.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalBrain Research
Volume807
Issue number1-2
DOIs
Publication statusPublished - Oct 5 1998
Externally publishedYes

Fingerprint

Glucagon-Like Peptide 1
Eating
Central Nervous System
Amino Acids
Feeding Behavior
Histidine
glucagon-like peptide 1 (7-36)

Keywords

  • Central
  • Chicken
  • Feeding behavior
  • Fragment
  • Glucagon-like peptide-1 (GLP-1)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of various N-terminal fragments of glucagon-like peptide-1(7- 36) on food intake in the neonatal chick. / Furuse, Mitsuhiro; Bungo, Takashi; Shimojo, Masataka; Masuda, Yasuhisa; Saito, Noboru; Hasegawa, Shin; Sugahara, Kunio.

In: Brain Research, Vol. 807, No. 1-2, 05.10.1998, p. 214-217.

Research output: Contribution to journalArticle

Furuse, Mitsuhiro ; Bungo, Takashi ; Shimojo, Masataka ; Masuda, Yasuhisa ; Saito, Noboru ; Hasegawa, Shin ; Sugahara, Kunio. / Effects of various N-terminal fragments of glucagon-like peptide-1(7- 36) on food intake in the neonatal chick. In: Brain Research. 1998 ; Vol. 807, No. 1-2. pp. 214-217.
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