Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats

S. Oka, K. Ogino, T. Hobara, S. Yoshimura, Y. Okazaki, T. Takemoto, Y. Iida

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalEuropean Journal of Pharmacology
Volume197
Issue number1
DOIs
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Ditiocarb
Protective Agents
Superoxide Dismutase
Ulcer
Gastric Mucosa
Mucus
Prostaglandins
Antral
Maintenance

Keywords

  • Cu,Zn-superoxide dismutase
  • diethyldithiocarbamate-induced antral ulcer
  • gastric mucosa
  • mucosal protective drugs

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats. / Oka, S.; Ogino, K.; Hobara, T.; Yoshimura, S.; Okazaki, Y.; Takemoto, T.; Iida, Y.

In: European Journal of Pharmacology, Vol. 197, No. 1, 1991, p. 99-102.

Research output: Contribution to journalArticle

Oka, S, Ogino, K, Hobara, T, Yoshimura, S, Okazaki, Y, Takemoto, T & Iida, Y 1991, 'Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats', European Journal of Pharmacology, vol. 197, no. 1, pp. 99-102. https://doi.org/10.1016/0014-2999(91)90370-6
Oka, S. ; Ogino, K. ; Hobara, T. ; Yoshimura, S. ; Okazaki, Y. ; Takemoto, T. ; Iida, Y. / Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats. In: European Journal of Pharmacology. 1991 ; Vol. 197, No. 1. pp. 99-102.
@article{c3230f9a19ac446cb0bb55e6c5fa86d1,
title = "Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats",
abstract = "This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.",
keywords = "Cu,Zn-superoxide dismutase, diethyldithiocarbamate-induced antral ulcer, gastric mucosa, mucosal protective drugs",
author = "S. Oka and K. Ogino and T. Hobara and S. Yoshimura and Y. Okazaki and T. Takemoto and Y. Iida",
year = "1991",
doi = "10.1016/0014-2999(91)90370-6",
language = "English",
volume = "197",
pages = "99--102",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats

AU - Oka, S.

AU - Ogino, K.

AU - Hobara, T.

AU - Yoshimura, S.

AU - Okazaki, Y.

AU - Takemoto, T.

AU - Iida, Y.

PY - 1991

Y1 - 1991

N2 - This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.

AB - This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.

KW - Cu,Zn-superoxide dismutase

KW - diethyldithiocarbamate-induced antral ulcer

KW - gastric mucosa

KW - mucosal protective drugs

UR - http://www.scopus.com/inward/record.url?scp=0025845171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025845171&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(91)90370-6

DO - 10.1016/0014-2999(91)90370-6

M3 - Article

C2 - 1654263

AN - SCOPUS:0025845171

VL - 197

SP - 99

EP - 102

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -