Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats

S. Oka, K. Ogino, T. Hobara, S. Yoshimura, Y. Okazaki, T. Takemoto, Y. Iida

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalEuropean Journal of Pharmacology
Volume197
Issue number1
Publication statusPublished - 1991
Externally publishedYes

Keywords

  • Cu,Zn-superoxide dismutase
  • diethyldithiocarbamate-induced antral ulcer
  • gastric mucosa
  • mucosal protective drugs

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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