Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats

Kazuaki Shinomiya, Katsuyuki Fujimura, Yonsu Kim, Chiaki Kamei

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalActa Medica Okayama
Volume59
Issue number3
Publication statusPublished - Jun 2005

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Valerian
Rats
Sleep
Eye Movements
Eye movements
Wakefulness
Herbal Medicine
REM Sleep

Keywords

  • Delta activity
  • Insomnia
  • Sleep latency
  • Sleep quality
  • Sleep-disturbed model
  • Valerian

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shinomiya, K., Fujimura, K., Kim, Y., & Kamei, C. (2005). Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. Acta Medica Okayama, 59(3), 89-92.

Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. / Shinomiya, Kazuaki; Fujimura, Katsuyuki; Kim, Yonsu; Kamei, Chiaki.

In: Acta Medica Okayama, Vol. 59, No. 3, 06.2005, p. 89-92.

Research output: Contribution to journalArticle

Shinomiya, K, Fujimura, K, Kim, Y & Kamei, C 2005, 'Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats', Acta Medica Okayama, vol. 59, no. 3, pp. 89-92.
Shinomiya K, Fujimura K, Kim Y, Kamei C. Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. Acta Medica Okayama. 2005 Jun;59(3):89-92.
Shinomiya, Kazuaki ; Fujimura, Katsuyuki ; Kim, Yonsu ; Kamei, Chiaki. / Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. In: Acta Medica Okayama. 2005 ; Vol. 59, No. 3. pp. 89-92.
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