Abstract
The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright
| Original language | English |
|---|---|
| Pages (from-to) | 89-92 |
| Number of pages | 4 |
| Journal | Acta Medica Okayama |
| Volume | 59 |
| Issue number | 3 |
| Publication status | Published - Jun 2005 |
Fingerprint
Keywords
- Delta activity
- Insomnia
- Sleep latency
- Sleep quality
- Sleep-disturbed model
- Valerian
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. / Shinomiya, Kazuaki; Fujimura, Katsuyuki; Kim, Yonsu; Kamei, Chiaki.
In: Acta Medica Okayama, Vol. 59, No. 3, 06.2005, p. 89-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats
AU - Shinomiya, Kazuaki
AU - Fujimura, Katsuyuki
AU - Kim, Yonsu
AU - Kamei, Chiaki
PY - 2005/6
Y1 - 2005/6
N2 - The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright
AB - The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright
KW - Delta activity
KW - Insomnia
KW - Sleep latency
KW - Sleep quality
KW - Sleep-disturbed model
KW - Valerian
UR - http://www.scopus.com/inward/record.url?scp=21644432648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21644432648&partnerID=8YFLogxK
M3 - Article
C2 - 16049561
AN - SCOPUS:21644432648
VL - 59
SP - 89
EP - 92
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 3
ER -