Abstract
The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright
| Original language | English |
|---|---|
| Pages (from-to) | 89-92 |
| Number of pages | 4 |
| Journal | Acta medica Okayama |
| Volume | 59 |
| Issue number | 3 |
| Publication status | Published - Jun 1 2005 |
Keywords
- Delta activity
- Insomnia
- Sleep latency
- Sleep quality
- Sleep-disturbed model
- Valerian
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)