Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats

Kazuaki Shinomiya, Katsuyuki Fujimura, Yonsu Kim, Chiaki Kamei

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The present study was performed to investigate the effects of valerian extract on the sleep-wake cycle using sleep-disturbed model rats. A significant shortening in sleep latency was observed with valerian extract at doses of 1000 and 3000 mg/kg. On the other hand, valerian extract had no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep, or REM sleep, even at a dose of 3000 mg/kg. Valerian extract at doses of 1000 and 3000 mg/kg showed a significant increase in the delta activity during non-REM sleep. In conclusion, valerian extract may be useful as an herbal medicine having not only sleep-inducing effects but also sleep quality-enhancement effects. Copyright

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalActa medica Okayama
Volume59
Issue number3
Publication statusPublished - Jun 1 2005

Keywords

  • Delta activity
  • Insomnia
  • Sleep latency
  • Sleep quality
  • Sleep-disturbed model
  • Valerian

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Shinomiya, K., Fujimura, K., Kim, Y., & Kamei, C. (2005). Effects of valerian extract on the sleep-wake cycle in sleep-disturbed rats. Acta medica Okayama, 59(3), 89-92.