Effects of therapeutic hypothermia for neuroprotection from the viewpoint of redox regulation

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7 Citations (Scopus)


Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalActa medica Okayama
Issue number1
Publication statusPublished - 2017


  • Intensive care
  • Oxidative stress
  • Post-cardiac arrest syndrome
  • Therapeutic hypothermia
  • Traumatic brain injury

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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