Abstract
Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Acta medica Okayama |
| Volume | 71 |
| Issue number | 1 |
| Publication status | Published - 2017 |
Keywords
- Intensive care
- Oxidative stress
- Post-cardiac arrest syndrome
- Therapeutic hypothermia
- Traumatic brain injury
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)