Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

Miyuki Nishiga, Yukio Sugimoto, Chiyomi Taga, Yoko Fujii, Chiaki Kamei

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We examined the effects of a histidine-deficient diet on brain histamine contents as well as on learning and memory using the eight-arm radial maze in rats. A significant decrease in histamine content in the hippocampus was observed after long-term feeding of rats with a histidine-deficient diet. At the same time, significant enhancement of the acquisition process in radial maze performance was also observed. Pyrilamine did not show a significant effect on radial maze performance in histidine-deficient rats. On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. Scopolamine was effective in inhibiting spatial memory in both histidine-deficient and control rats. MK-801 caused spatial memory deficits more potently in histidine-deficient rats than in controls. Brain glycine contents showed a significant increase in the hippocampus in histidine-deficient rats. These results indicated that the spatial memory deficits induced by MK-801 in histidine-deficient rats are closely related to increased glycine levels and activation of NMDA receptors.

Original languageEnglish
Pages (from-to)2199-2208
Number of pages10
JournalLife Sciences
Volume70
Issue number18
DOIs
Publication statusPublished - Mar 22 2002

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Dizocilpine Maleate
N-Methylaspartate
Histidine
Rats
Data storage equipment
Rat control
Memory Disorders
Pyrilamine
Nutrition
Glycine
Histamine
Brain
Hippocampus
Diet
Scopolamine Hydrobromide
N-Methyl-D-Aspartate Receptors
Chemical activation
Learning
Spatial Memory

Keywords

  • Glycine
  • Histamine
  • Histidine
  • Learning and memory
  • MK-801
  • Radial maze

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats. / Nishiga, Miyuki; Sugimoto, Yukio; Taga, Chiyomi; Fujii, Yoko; Kamei, Chiaki.

In: Life Sciences, Vol. 70, No. 18, 22.03.2002, p. 2199-2208.

Research output: Contribution to journalArticle

Nishiga, Miyuki ; Sugimoto, Yukio ; Taga, Chiyomi ; Fujii, Yoko ; Kamei, Chiaki. / Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats. In: Life Sciences. 2002 ; Vol. 70, No. 18. pp. 2199-2208.
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