Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

Tsutomu Hatano; Miwako Kusuda; Kazutoshi Inada; Tomo Omi Ogawa; Sumiko Shiota; Tomofusa Tsuchiya; Takashi Yoshida

doi:10.1016/j.phytochem.2005.01.013

Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

Tsutomu Hatano, Miwako Kusuda, Kazutoshi Inada, Tomo Omi Ogawa, Sumiko Shiota, Tomofusa Tsuchiya, Takashi Yoshida

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.

Original language	English
Pages (from-to)	2047-2055
Number of pages	9
Journal	Phytochemistry
Volume	66
Issue number	17 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.phytochem.2005.01.013
Publication status	Published - Sep 2005

Keywords

Antibacterial
Antibiotic resistance
Camellia sinensis (Theaceae)
MRSA
Polyphenol
Proanthocyanidin
Tannin
Tea
Zanthoxylum piperitum (Rutaceae)
Zizyphus jujuba var. inermis (Rhamnaceae)

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2005.01.013

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title = "Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.",

keywords = "Antibacterial, Antibiotic resistance, Camellia sinensis (Theaceae), MRSA, Polyphenol, Proanthocyanidin, Tannin, Tea, Zanthoxylum piperitum (Rutaceae), Zizyphus jujuba var. inermis (Rhamnaceae)",

author = "Tsutomu Hatano and Miwako Kusuda and Kazutoshi Inada and Ogawa, {Tomo Omi} and Sumiko Shiota and Tomofusa Tsuchiya and Takashi Yoshida",

year = "2005",

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doi = "10.1016/j.phytochem.2005.01.013",

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AU - Hatano, Tsutomu

AU - Kusuda, Miwako

AU - Inada, Kazutoshi

AU - Ogawa, Tomo Omi

AU - Shiota, Sumiko

AU - Tsuchiya, Tomofusa

AU - Yoshida, Takashi

PY - 2005/9

Y1 - 2005/9

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.

KW - Antibacterial

KW - Antibiotic resistance

KW - Camellia sinensis (Theaceae)

KW - MRSA

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KW - Proanthocyanidin

KW - Tannin

KW - Tea

KW - Zanthoxylum piperitum (Rutaceae)

KW - Zizyphus jujuba var. inermis (Rhamnaceae)

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ER -

Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

Abstract

Keywords

ASJC Scopus subject areas

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