Effects of tannins and related polyphenols on methicillin-resistant Staphylococcus aureus

Tsutomu Hatano, Miwako Kusuda, Kazutoshi Inada, Tomo Omi Ogawa, Sumiko Shiota, Tomofusa Tsuchiya, Takashi Yoshida

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)


Methicillin-resistant Staphylococcus aureus (MRSA) often acquires multi-drug resistance and is involved in many cases of disease in hospitals. We investigated natural substances directly effective against MRSA or that influence antibiotic resistance. Aloe-emodin, an anthraquinone, and several licorice flavonoids showed potent antibacterial effects against MRSA. Like some hydrolysable tannins (corilagin and tellimagrandin I) and a tea polyphenol [(-)-epicatechin gallate], the licorice flavonoid licoricidin also restored the effects of oxacillin, a β-lactam antibiotic against MRSA. Further study revealed that theasinensin A, a polyphenol formed from (-)-epigallocatechin gallate, proanthocyanidins obtained from fruits of Zizyphus jujuba var. inermis, and polymeric proanthocyanidins from fruit peels of Zanthoxylum piperitum also suppressed the antibiotic resistance of MRSA.

Original languageEnglish
Pages (from-to)2047-2055
Number of pages9
Issue number17 SPEC. ISS.
Publication statusPublished - Sep 2005


  • Antibacterial
  • Antibiotic resistance
  • Camellia sinensis (Theaceae)
  • MRSA
  • Polyphenol
  • Proanthocyanidin
  • Tannin
  • Tea
  • Zanthoxylum piperitum (Rutaceae)
  • Zizyphus jujuba var. inermis (Rhamnaceae)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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