Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa

Yuji Kurosaki, Shin ichi Hisaichi, Chieko Hamada, Taiji Nakayama, Toshikiro Kimura

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume47
Issue number1-3
DOIs
Publication statusPublished - 1988

Fingerprint

Salicylic Acid
Cheek
Mouth Mucosa
Surface-Active Agents
Cricetinae
Cetylpyridinium
Taurocholic Acid
Polysorbates
Sodium Chloride
Permeability
Sodium
Pharmaceutical Preparations

Keywords

  • Hamster cheek pouch
  • Keratinized oral mucosa
  • Micellar complex formation
  • Salicylic acid
  • Surfactant

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa. / Kurosaki, Yuji; Hisaichi, Shin ichi; Hamada, Chieko; Nakayama, Taiji; Kimura, Toshikiro.

In: International Journal of Pharmaceutics, Vol. 47, No. 1-3, 1988, p. 13-19.

Research output: Contribution to journalArticle

Kurosaki, Yuji ; Hisaichi, Shin ichi ; Hamada, Chieko ; Nakayama, Taiji ; Kimura, Toshikiro. / Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa. In: International Journal of Pharmaceutics. 1988 ; Vol. 47, No. 1-3. pp. 13-19.
@article{c10f1a5da7c946eda18c2f86a53170d3,
title = "Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa",
abstract = "The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.",
keywords = "Hamster cheek pouch, Keratinized oral mucosa, Micellar complex formation, Salicylic acid, Surfactant",
author = "Yuji Kurosaki and Hisaichi, {Shin ichi} and Chieko Hamada and Taiji Nakayama and Toshikiro Kimura",
year = "1988",
doi = "10.1016/0378-5173(88)90210-4",
language = "English",
volume = "47",
pages = "13--19",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa

AU - Kurosaki, Yuji

AU - Hisaichi, Shin ichi

AU - Hamada, Chieko

AU - Nakayama, Taiji

AU - Kimura, Toshikiro

PY - 1988

Y1 - 1988

N2 - The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.

AB - The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.

KW - Hamster cheek pouch

KW - Keratinized oral mucosa

KW - Micellar complex formation

KW - Salicylic acid

KW - Surfactant

UR - http://www.scopus.com/inward/record.url?scp=0023771675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023771675&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(88)90210-4

DO - 10.1016/0378-5173(88)90210-4

M3 - Article

VL - 47

SP - 13

EP - 19

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-3

ER -