Abstract
The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 13-19 |
| Number of pages | 7 |
| Journal | International Journal of Pharmaceutics |
| Volume | 47 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 1988 |
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Keywords
- Hamster cheek pouch
- Keratinized oral mucosa
- Micellar complex formation
- Salicylic acid
- Surfactant
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa. / Kurosaki, Yuji; Hisaichi, Shin ichi; Hamada, Chieko; Nakayama, Taiji; Kimura, Toshikiro.
In: International Journal of Pharmaceutics, Vol. 47, No. 1-3, 1988, p. 13-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of surfactants on the absorption of salicylic acid from hamster cheek pouch as a model of keratinized oral mucosa
AU - Kurosaki, Yuji
AU - Hisaichi, Shin ichi
AU - Hamada, Chieko
AU - Nakayama, Taiji
AU - Kimura, Toshikiro
PY - 1988
Y1 - 1988
N2 - The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.
AB - The effect of surfactants on the absorption of salicylic acid from keratinized oral mucosa was investigated by hamster cheek pouch method in vivo at pHs 3.0, 4.0 and 7.0. Four surfactants, sodium laurylsulfate (SLS), cetylpyridinium chloride (CPC), polysorbate 80 (PS-80) and sodium taurocholate (STC), were examined as adjuvants. The interaction between salicylic acid and each surfactant was determined by the molecular sieve method using Sephadex G-25. Decreased absorption of salicylic acid by the presence of PS-80 was observed in the lower pH conditions and this phenomenon was explained by the decrease in the free fraction of salicylic acid. The absorption of salicylic acid in the presence of ionic surfactants, SLS or CPC, was much larger than that predicted by the loss of activities which was caused by the interaction between the surfactant and the drug molecule. Pretreatment with SLC or CPC brought the salicylic acid absorption to increase in all pH conditions examined and the effects were dependent on the surfactant concentration. STC and no effect on the absorption. The mechanisms of the effects of ionic surfactants on the permeability of keratinized oral mucosa were discussed.
KW - Hamster cheek pouch
KW - Keratinized oral mucosa
KW - Micellar complex formation
KW - Salicylic acid
KW - Surfactant
UR - http://www.scopus.com/inward/record.url?scp=0023771675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023771675&partnerID=8YFLogxK
U2 - 10.1016/0378-5173(88)90210-4
DO - 10.1016/0378-5173(88)90210-4
M3 - Article
VL - 47
SP - 13
EP - 19
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-3
ER -