Effects of submaxillariectomy on ovarian androgen and estrogen production in adult female rats

Masami Tanaka; Minoru Watanabe; Toshio Kumai; Hironori Nakura; Shinichi Kobayashi

doi:10.1006/bbrc.1995.2166

Effects of submaxillariectomy on ovarian androgen and estrogen production in adult female rats

Masami Tanaka, Minoru Watanabe, Toshio Kumai, Hironori Nakura, Shinichi Kobayashi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Submaxillariectomy causes an increase in uterine weight in adult female rats. This increase is due to the elevation of the plasma 17β-estradiol (E₂) level which is brought on by enhancement of ovarian E₂ production. Furthermore, enhancement of ovarian E₂ production is due to the enhancement of testosterone and androstenedione production which are the precursors of ovarian E₂. However, submaxillariectomy did not affect ovarian progesterone and 17α-hydroxyprogesterone levels. These findings suggest that the submaxillary gland may inhibit the production of ovarian E₂ mainly because of the inhibition of ovarian androgen production. Thus the submaxillary gland may play a physiological role in female reproductive systems caused by the change in ovarian steroidogenesis.

Original language	English
Pages (from-to)	550-554
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	213
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1995.2166
Publication status	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Effects of submaxillariectomy on ovarian androgen and estrogen production in adult female rats",

abstract = "Submaxillariectomy causes an increase in uterine weight in adult female rats. This increase is due to the elevation of the plasma 17β-estradiol (E2) level which is brought on by enhancement of ovarian E2 production. Furthermore, enhancement of ovarian E2 production is due to the enhancement of testosterone and androstenedione production which are the precursors of ovarian E2. However, submaxillariectomy did not affect ovarian progesterone and 17α-hydroxyprogesterone levels. These findings suggest that the submaxillary gland may inhibit the production of ovarian E2 mainly because of the inhibition of ovarian androgen production. Thus the submaxillary gland may play a physiological role in female reproductive systems caused by the change in ovarian steroidogenesis.",

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T1 - Effects of submaxillariectomy on ovarian androgen and estrogen production in adult female rats

AU - Tanaka, Masami

AU - Watanabe, Minoru

AU - Kumai, Toshio

AU - Nakura, Hironori

AU - Kobayashi, Shinichi

PY - 1995

Y1 - 1995

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AB - Submaxillariectomy causes an increase in uterine weight in adult female rats. This increase is due to the elevation of the plasma 17β-estradiol (E2) level which is brought on by enhancement of ovarian E2 production. Furthermore, enhancement of ovarian E2 production is due to the enhancement of testosterone and androstenedione production which are the precursors of ovarian E2. However, submaxillariectomy did not affect ovarian progesterone and 17α-hydroxyprogesterone levels. These findings suggest that the submaxillary gland may inhibit the production of ovarian E2 mainly because of the inhibition of ovarian androgen production. Thus the submaxillary gland may play a physiological role in female reproductive systems caused by the change in ovarian steroidogenesis.

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Effects of submaxillariectomy on ovarian androgen and estrogen production in adult female rats

Abstract

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