Effects of short-acting hypnotics on sleep latency in rats placed on grid suspended over water

Kazuaki Shinomiya, Yuki Shigemoto, Chihiro Okuma, Mitsunobu Mio, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

The present study was performed to develop a new sleep disturbance model for evaluating hypnotic potencies by placing rats on a grid suspended over water up to 1 cm under the grid surface. When rats were placed on the grid, significant increases in sleep latency and amount of wakefulness were observed compared with those of rats placed on sawdust. However, the amounts of non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep of rats placed on the grid were significantly decreased compared with those of rats placed on sawdust. Four short-acting hypnotics (triazolam, zopiclone, brotizolam, lormetazepam) caused significant decreases in sleep latency, and the effects of hypnotics in rats placed on the grid were more potent than those in rats placed on sawdust. In conclusion, the present model can serve as a new sleep disturbance model and may also be useful for evaluating the sleep-inducing effects of short-acting hypnotics.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalEuropean Journal of Pharmacology
Volume460
Issue number2-3
DOIs
Publication statusPublished - Jan 24 2003

Keywords

  • Insomnia
  • Non-rapid eye movement (non-REM) sleep
  • Rapid eye movement (REM) sleep
  • Short-acting hypnotic
  • Sleep latency
  • Wakefulness

ASJC Scopus subject areas

  • Pharmacology

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