Effects of radiofrequency ablation on individual renal function: Assessment by technetium-99m mercaptoacetyltriglycine renal scintigraphy

Takashi Mukai, Shuhei Sato, Toshihiro Iguchi, Hidefumi Mimura, Kotaro Yasui, Hideo Gobara, Takashi Saika, Yasutomo Nasu, Hiromi Kumon, Susumu Kanazawa

Research output: Contribution to journalArticle

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Abstract

We quantitatively evaluated total and individual renal function by technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renal scintigraphy before and after radiofrequency ablation (RFA) of renal tumors. Eleven patients who underwent Tc-99m MAG3 renal scintigraphy 1 week before and after RFA were evaluated (7 men and 4 women; age range: 23-83 years; mean age: 60.6 years). Five patients had solitary kidneys, and five had normally or minimally functioning contralateral kidneys. One patient had a renal cell carcinoma in the contralateral kidney. One patient with a solitary kidney underwent RFA a second time for a residual tumor. In patients with a solitary kidney, MAG3 clearance decreased after 5 of 6 RFAs, and in patients with a normally functioning contralateral kidney, MAG3 clearance decreased after 4 of 5 RFAs, but no significant differences were observed between before and after treatments. In addition to the total MAG3 clearance, the split MAG3 clearance was evaluated in patients with a normally functioning contralateral kidney. MAG3 clearance decreased in 4 of 5 treated kidneys, while it adversely increased in the contralateral kidneys after 4 of 5 RFAs. No significant differences, however, were observed between before and after treatments. The results of our study revealed no significant differences in sCr, BUN, CCr, or MAG3 clearance between pre- and post-RFA values. These results support data regarding the functional impact and safety of renal RFA in published reports. We evaluated total and individual renal function quantitatively using Tc-99m MAG3 renal scintigraphy before and after treatment. This scintigraphy was very useful in assessing the effects of RFA on renal function. Copyright

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalActa Medica Okayama
Volume60
Issue number2
Publication statusPublished - Apr 2006

Fingerprint

Technetium Tc 99m Mertiatide
Ablation
Radionuclide Imaging
Kidney
Tumors
Cells

Keywords

  • Individual renal function
  • Kidney
  • Radiofrequency ablation
  • Renal tumor
  • Tc-99m MAG3 renal scintigraphy

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effects of radiofrequency ablation on individual renal function : Assessment by technetium-99m mercaptoacetyltriglycine renal scintigraphy. / Mukai, Takashi; Sato, Shuhei; Iguchi, Toshihiro; Mimura, Hidefumi; Yasui, Kotaro; Gobara, Hideo; Saika, Takashi; Nasu, Yasutomo; Kumon, Hiromi; Kanazawa, Susumu.

In: Acta Medica Okayama, Vol. 60, No. 2, 04.2006, p. 85-91.

Research output: Contribution to journalArticle

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