Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats

Kouhei Kitagawa, Yoshihisa Kitamura, Toshiaki Miyazaki, Junya Miyaoka, Hiromu Kawasaki, Masato Asanuma, Toshiaki Sendo, Yutaka Gomita

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The dopamine D2/D3 receptor agonist pramipexole has clinically been proven to improve depression or treatment-resistant depression. However, the involvement of the dopamine receptor system on the effect of pramipexole on depression remains unclear. We examined the influence of pramipexole on the duration of immobility during the forced swim test in normal and adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which pramipexole acts in this model was explored specifically in relation to the site of action through the use of microinjections into the intramedial prefrontal cortex and nucleus accumbens. Pramipexole (0.3-1 mg/kg) significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by L-741,626, a D2 receptor antagonist, and nafadotride, a D3 receptor antagonist, in normal rats. Furthermore, infusions of pramipexole into the intranucleus accumbens, but not the medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Taken together, the results of these experiments suggested that pramipexole, administered into the intranucleus accumbens rather than the medial prefrontal cortex, exerted an antidepressant-like effect on ACTH-treated rats via the dopaminergic system. The immobility-decreasing effect of pramipexole may be mediated by dopamine D2 and D3 receptors.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume380
Issue number1
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Dopamine receptor
  • Forced swim test
  • Nucleus accumbens
  • Pramipexole
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats'. Together they form a unique fingerprint.

  • Cite this