Effects of phenytoin on convulsions and brain 5-hydroxytryptamine levels in E1 mice

Yousuke Matsumoto, M. Hiramatsu, A. Mori

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E1 mice have a convulsive disposition and the convulsions are easily induced by 'tossing' stimulation. The mice were 'tossed up' to a height of 10 cm, once a week from 4 weeks of age and one stimulation had 80 'tosses'. In the present study effects of phenytoin (PHT) on convulsions and brain 5-hydroxytryptamine (5-HT) level in the E1 mice were studied. The daily i.p. administration of PHT (40 mg/kg, twice a day) for 3 days completely inhibited the E1 mice convulsions. At that time the 5-HT levels of brainstem and cerebellum of the E1 mice were remarkably higher. Previously we have found that the brain 5-HT levels were lower in the interictal period of E1 mice and the administration of 5-hydroxytryptophan with MK486 absolutely inhibited the convulsions of E1 mice. These results suggest that sensitivity to convulsions may be related to the decreased level of brain 5-HT in the E1 mice.

Original languageEnglish
Pages (from-to)837
Number of pages1
JournalIRCS Medical Science
Issue number9
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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