Abstract
Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
| Original language | English |
|---|---|
| Pages (from-to) | 867-872 |
| Number of pages | 6 |
| Journal | Phytotherapy Research |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2008 |
| Externally published | Yes |
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Keywords
- B16-F10 melanoma cell
- Enmein
- Pedalitin
- Quercetin
- Rabdosia japonica
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells. / Nitoda, Teruhiko; Isobe, Takahiko; Kubo, Isao.
In: Phytotherapy Research, Vol. 22, No. 7, 07.2008, p. 867-872.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells
AU - Nitoda, Teruhiko
AU - Isobe, Takahiko
AU - Kubo, Isao
PY - 2008/7
Y1 - 2008/7
N2 - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
AB - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
KW - B16-F10 melanoma cell
KW - Enmein
KW - Pedalitin
KW - Quercetin
KW - Rabdosia japonica
UR - http://www.scopus.com/inward/record.url?scp=48749128263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48749128263&partnerID=8YFLogxK
U2 - 10.1002/ptr.2373
DO - 10.1002/ptr.2373
M3 - Article
C2 - 18567053
AN - SCOPUS:48749128263
VL - 22
SP - 867
EP - 872
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 7
ER -