Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda; Takahiko Isobe; Isao Kubo

doi:10.1002/ptr.2373

Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC₅₀ of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

Original language	English
Pages (from-to)	867-872
Number of pages	6
Journal	Phytotherapy Research
Volume	22
Issue number	7
DOIs	https://doi.org/10.1002/ptr.2373
Publication status	Published - Jul 1 2008
Externally published	Yes

Keywords

B16-F10 melanoma cell
Enmein
Pedalitin
Quercetin
Rabdosia japonica

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1002/ptr.2373

Cite this

@article{a25c8ea680c0476586dc3b0b29a5c21d,

title = "Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells",

abstract = "Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.",

keywords = "B16-F10 melanoma cell, Enmein, Pedalitin, Quercetin, Rabdosia japonica",

author = "Teruhiko Nitoda and Takahiko Isobe and Isao Kubo",

year = "2008",

month = jul,

day = "1",

doi = "10.1002/ptr.2373",

language = "English",

volume = "22",

pages = "867--872",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

AU - Nitoda, Teruhiko

AU - Isobe, Takahiko

AU - Kubo, Isao

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

AB - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

KW - B16-F10 melanoma cell

KW - Enmein

KW - Pedalitin

KW - Quercetin

KW - Rabdosia japonica

UR - http://www.scopus.com/inward/record.url?scp=48749128263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48749128263&partnerID=8YFLogxK

U2 - 10.1002/ptr.2373

DO - 10.1002/ptr.2373

M3 - Article

C2 - 18567053

AN - SCOPUS:48749128263

VL - 22

SP - 867

EP - 872

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 7

ER -

Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this