Abstract
Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
Original language | English |
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Pages (from-to) | 867-872 |
Number of pages | 6 |
Journal | Phytotherapy Research |
Volume | 22 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 1 2008 |
Externally published | Yes |
Keywords
- B16-F10 melanoma cell
- Enmein
- Pedalitin
- Quercetin
- Rabdosia japonica
ASJC Scopus subject areas
- Pharmacology