Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

Original languageEnglish
Pages (from-to)867-872
Number of pages6
JournalPhytotherapy Research
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2008
Externally publishedYes

Keywords

  • B16-F10 melanoma cell
  • Enmein
  • Pedalitin
  • Quercetin
  • Rabdosia japonica

ASJC Scopus subject areas

  • Pharmacology

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