Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

Original languageEnglish
Pages (from-to)867-872
Number of pages6
JournalPhytotherapy Research
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 2008
Externally publishedYes

Fingerprint

flavone
Isodon
Lamiaceae
Rutin
Experimental Melanomas
Melanins
Quercetin
Cytotoxicity
Inhibitory Concentration 50
Cultured Cells
Cells
Antennas
Cell Line
pedalitin

Keywords

  • B16-F10 melanoma cell
  • Enmein
  • Pedalitin
  • Quercetin
  • Rabdosia japonica

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells. / Nitoda, Teruhiko; Isobe, Takahiko; Kubo, Isao.

In: Phytotherapy Research, Vol. 22, No. 7, 07.2008, p. 867-872.

Research output: Contribution to journalArticle

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