Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda; Takahiko Isobe; Isao Kubo

doi:10.1002/ptr.2373

Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells

Teruhiko Nitoda, Takahiko Isobe, Isao Kubo

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC₅₀ of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

Original language	English
Pages (from-to)	867-872
Number of pages	6
Journal	Phytotherapy Research
Volume	22
Issue number	7
DOIs	https://doi.org/10.1002/ptr.2373
Publication status	Published - Jul 1 2008
Externally published	Yes

Keywords

B16-F10 melanoma cell
Enmein
Pedalitin
Quercetin
Rabdosia japonica

ASJC Scopus subject areas

Pharmacology

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10.1002/ptr.2373

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abstract = "Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.",

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AB - Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC50 of 30 μm (9.5 μg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.

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