Effects of perilia seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism

Makoto Okamoto, Fumihiro Mitsunobu, Kozo Ashida, Takashi Mifune, Yasuhiro Hosaki, Hirofumi Tsugeno, Seishi Harada, Yoshiro Tanizaki, Mikio Kataoka, Kenji Niiya, Mine Harada

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Dietary sources of α-linolenic acid, such as perilia seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with asthma, as has been reported with the consumption of other long-chain n-3 fatty acids. Methods: The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilia seed oil (n-3 fatty acids). Group A consisted of patients in whom the leucocyte generation of LTC4 was suppressed by dietary perilla seed oil. Group B consisted of those in whom LTC4 generation was not suppressed. Results: LTC4 generation by leucocytes decreased significantly in group A after 2 (p < 0.05) and 4 weeks (p < 0.05); conversely, it increased significantly in group B after 4 weeks (p < 0.05). The two study groups differed significantly in terms of LTC4 generation by leucocytes after 4 weeks of dietary supplementation (p < 0.05). Ventilatory parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05). Values of PEF, FVC, FEV1 and maximum expiratory flow at 25% of the forced vital capacity (V25) differed significantly between groups A and B prior to dietary supplementation. Serum levels of total cholesterol, low-density ipoprotein (LDL) cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks. Serum levels of total cholesterol, triglyceride, high- density lipoprotein cholesterol, LDL cholesterol and phospholipid differed significantly between the two study groups prior to dietary supplementation. Serum levels of triglyceride and LDL cholesterol differed significantly between the two study groups after 4 weeks of dietary supplementation. Conclusions: Dietary supplementation with perilla seed oil in selected patients with asthma suppresses the generation of LTC4 and is associated with clinical features such as respiratory function and lipometabolism. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume122
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Bronchial asthma
  • Leukotrienes
  • Lipometabolism
  • Perilla seed oil

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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