Effects of peppermint (Mentha piperita L.) extracts on experimental allergic rhinitis in rats

Toshio Inoue, Yukio Sugimoto, Hideki Masuda, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The present study was carried out to clarify the effects of extracts of the leaves of Mentha piperita L. on experimental allergic rhinitis. The 50% EtOH extract of peppermint inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. The effect was dose-dependent and significant inhibition was observed at a concentration of 3 μg/ml. In addition, the 50% EtOH eluate separated from the 50% EtOH extract of peppermint by column chromatography (DIAION HP-20) was also effective in inhibiting histamine release at a concentration of 1 μg/ml. Nasal symptoms, sneezing and nasal rubbing induced by antigen challenge in actively sensitized rats were inhibited by oral administration of the 50% EtOH eluate. Significant inhibition of sneezing and nasal rubbing was observed at doses of 300 and 1000 mg/kg, p.o., respectively. Furthermore, the 50% EtOH eluate inhibited dye leakage into the nasal cavity of rats induced by antigen in a dose-dependent manner. These results suggested that extracts of Mentha piperita L. may be clinically effective in alleviating the nasal symptoms of allergic rhinitis.

Original languageEnglish
Pages (from-to)92-95
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume24
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Experimental allergic model
  • Histamine release
  • Mentha piperita L.
  • Nasal rubbing
  • Sneezing

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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