Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates

K. Tsuru, Y. Higashi, Satoshi Hayakawa, A. Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.

Original languageEnglish
Title of host publicationCeramic Transactions
EditorsV. Sundar, R.P. Rusin, C.A. Rutiser
Pages103-110
Number of pages8
Volume147
Publication statusPublished - 2003
EventBioceramics: Materials and Applications IV, Proceedings - Nashville, TN, United States
Duration: Apr 27 2003Apr 30 2003

Publication series

NameCeramic Transactions
Volume147

Other

OtherBioceramics: Materials and Applications IV, Proceedings
CountryUnited States
CityNashville, TN
Period4/27/034/30/03

Fingerprint

Apatites
Bioactive glass
Body fluids
Apatite
Titanium
Molecules
Substrates
Calcium
Organic acids
Albumins
Nucleation
Ions
Acids
Citric acid
Succinic Acid
Citric Acid
Screening
Heating
Glass

ASJC Scopus subject areas

  • Ceramics and Composites

Cite this

Tsuru, K., Higashi, Y., Hayakawa, S., & Osaka, A. (2003). Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. In V. Sundar, R. P. Rusin, & C. A. Rutiser (Eds.), Ceramic Transactions (Vol. 147, pp. 103-110). (Ceramic Transactions; Vol. 147).

Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. / Tsuru, K.; Higashi, Y.; Hayakawa, Satoshi; Osaka, A.

Ceramic Transactions. ed. / V. Sundar; R.P. Rusin; C.A. Rutiser. Vol. 147 2003. p. 103-110 (Ceramic Transactions; Vol. 147).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tsuru, K, Higashi, Y, Hayakawa, S & Osaka, A 2003, Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. in V Sundar, RP Rusin & CA Rutiser (eds), Ceramic Transactions. vol. 147, Ceramic Transactions, vol. 147, pp. 103-110, Bioceramics: Materials and Applications IV, Proceedings, Nashville, TN, United States, 4/27/03.
Tsuru K, Higashi Y, Hayakawa S, Osaka A. Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. In Sundar V, Rusin RP, Rutiser CA, editors, Ceramic Transactions. Vol. 147. 2003. p. 103-110. (Ceramic Transactions).
Tsuru, K. ; Higashi, Y. ; Hayakawa, Satoshi ; Osaka, A. / Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates. Ceramic Transactions. editor / V. Sundar ; R.P. Rusin ; C.A. Rutiser. Vol. 147 2003. pp. 103-110 (Ceramic Transactions).
@inproceedings{b1313765fbf447f781cc43784aa5832e,
title = "Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates",
abstract = "Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.",
author = "K. Tsuru and Y. Higashi and Satoshi Hayakawa and A. Osaka",
year = "2003",
language = "English",
volume = "147",
series = "Ceramic Transactions",
pages = "103--110",
editor = "V. Sundar and R.P. Rusin and C.A. Rutiser",
booktitle = "Ceramic Transactions",

}

TY - GEN

T1 - Effects of organic molecules in the Kokubo's simulated body fluid on apatite formation on bioactive glass and titanium substrates

AU - Tsuru, K.

AU - Higashi, Y.

AU - Hayakawa, Satoshi

AU - Osaka, A.

PY - 2003

Y1 - 2003

N2 - Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.

AB - Kokubo's simulated body fluid (SBF) has been extensively used for screening to distinguish bioactive materials. The present study examined the effects of organic acids and albumin in the SBF on apatite formation on glass and titanium substrates. Titanium substrates were subject to a H2O2 treatment and subsequent heating to prepare bioactive titania layers. Apatite formation was then examined after soaking the substrates in both SBF and modified SBF containing organic components such as succinic acid, tartaric acid, citric acid and albumin. Calcium-chelate formation due to the organics reduced free calcium ion concentration. The induction time of apatite nucleation on the titania surface was delayed in SBF containing the organic acids. The reduction in the free calcium ion concentration suppressed the apatite nucleation.

UR - http://www.scopus.com/inward/record.url?scp=2142710957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142710957&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:2142710957

VL - 147

T3 - Ceramic Transactions

SP - 103

EP - 110

BT - Ceramic Transactions

A2 - Sundar, V.

A2 - Rusin, R.P.

A2 - Rutiser, C.A.

ER -