Effects of nutrition on neutrophil function in preclinical studies

Keisuke Kohama, Joji Kotani, Atsunori Nakao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although neutrophils are an essential component of natural immunity, their activities must be carefully regulated to prevent detrimental prolonging of inflammation. To resolve inflammation, neutrophil recruitment to the affected tissue must be blocked, and neutrophils in the tissue must be removed by apoptosis and phagocytosis. Polyunsaturated fatty acids (PUFAs) are a major dietary regulator of immune function. N-3 PUFAs and n-6 PUFAs modulate the inflammatory response in neutrophils. N-3 PUFA exhibits anti-inflammatory activities through neutrophils using multiple mechanisms including decreasing neutrophil chemotaxis in response to inflammatory stimuli, reducing neutrophil adhesion to the vascular endothelium and neutrophil transmigration across the endothelium and into the affected tissue, and promotes the synthesis of resolvins and protectins, inflammation-resolving lipids that promote neutrophil apoptosis and phagocytosis. Sepsis and acute respiratory distress syndrome, common conditions in critical care patients, are both a result of dysregulated or excessive inflammation. Preclinical data obtained from rodent models and cell culture studies support a role in nutritional immunomodulation using n-3 PUFAs or their derivatives in patients with sepsis or acute lung injury.

Original languageEnglish
Title of host publicationDiet and Nutrition in Critical Care
PublisherSpringer New York
Pages1165-1178
Number of pages14
ISBN (Electronic)9781461478362
ISBN (Print)9781461478379
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Nutrition
Neutrophils
Tissue
Unsaturated Fatty Acids
CD59 Antigens
Apoptosis
Inflammation
Cell culture
Anti-Inflammatory Agents
Adhesion
Phagocytosis
Derivatives
Lipids
Sepsis
Immunomodulation
Neutrophil Infiltration
Acute Lung Injury
Adult Respiratory Distress Syndrome
Vascular Endothelium

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kohama, K., Kotani, J., & Nakao, A. (2015). Effects of nutrition on neutrophil function in preclinical studies. In Diet and Nutrition in Critical Care (pp. 1165-1178). Springer New York. https://doi.org/10.1007/978-1-4614-7836-2_87

Effects of nutrition on neutrophil function in preclinical studies. / Kohama, Keisuke; Kotani, Joji; Nakao, Atsunori.

Diet and Nutrition in Critical Care. Springer New York, 2015. p. 1165-1178.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kohama, K, Kotani, J & Nakao, A 2015, Effects of nutrition on neutrophil function in preclinical studies. in Diet and Nutrition in Critical Care. Springer New York, pp. 1165-1178. https://doi.org/10.1007/978-1-4614-7836-2_87
Kohama K, Kotani J, Nakao A. Effects of nutrition on neutrophil function in preclinical studies. In Diet and Nutrition in Critical Care. Springer New York. 2015. p. 1165-1178 https://doi.org/10.1007/978-1-4614-7836-2_87
Kohama, Keisuke ; Kotani, Joji ; Nakao, Atsunori. / Effects of nutrition on neutrophil function in preclinical studies. Diet and Nutrition in Critical Care. Springer New York, 2015. pp. 1165-1178
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