Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: A randomized double-blind clinical trial

K. Takeuchi-Hatanaka, T. Yasuda, K. Naruishi, K. Katsuragi-Fuke, J. Inubushi, H. Ootsuki, H. Maeda, S. Takashiba

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Objective: The biochemical effects of an over-the-counter (OTC) medication were studied, which consists of a single-tuft brush containing cetylpyridinium chloride as a bactericidal agent, dipotassium glycyrrhizate as an anti-inflammatory drug and allantoin as a promoter of cell proliferation and wound healing, for delivery to hardly brushed sites. Material and Methods: This randomized controlled double-blind study was performed in 61 subjects with chronic periodontitis in supportive periodontal therapy phase (test group: n = 27; placebo group: n = 28; dropout: n = 6). The OTC medication was self-applied twice a day for 12 wk to two molars with probing pocket depths of 4-6 mm. Biochemical indicators were evaluated at baseline and 12 wk using the suspension array system for eight cytokines and chemokines (interleukin [IL]-1β, IL-1ra, IL-4, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1 and tumor necrosis factor [TNF]-α) in gingival crevicular fluid. Results: The levels of IL-1β, IL-6, IL-8 and TNF-α remained significantly lower in the test group compared to the placebo group. In the placebo group, when the probing pocket depth at baseline was 4 mm, IL-1β increased, particularly in the second molar tooth, and the greatest increase was seen when PPD at baseline was 5-6 mm. In the test group, IL-1β decreased markedly in cases with furcation involvement and low bleeding on probing at baseline. In both groups, IL-1β, IL-6 and TNF-α were closely correlated with each other. Conclusion: This OTC medication is biochemically effective for steady chronic periodontitis in the supportive periodontal therapy phase.

Original languageEnglish
Pages (from-to)321-331
Number of pages11
JournalJournal of Periodontal Research
Volume51
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Inflammatory cytokine
  • Over-the-counter medication
  • Self-medication
  • Supportive periodontal therapy

ASJC Scopus subject areas

  • Periodontics

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