Effects of neurotensin on neurons in the rat central amygdaloid nucleus in vitro

Yun Fei Lu, Akiyoshi Moriwaki, Yasushi Hayashi, Kazuhito Tomizawa, Toshifumi Itano, Hideki Matsui

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Abstract

The effects of neurotensin (NT) on neurons in the central amygdaloid nucleus (ACe) were investigated in rat brain slice preparations by adding the peptide to the perfusing medium. Of 115 ACe neurons, 69 cells (60%) showed excitatory responses and 10 cells (9%) showed inhibitory responses to application of NT. The excitatory response to NT was observed in a dose- dependent manner and the threshold concentration was approximately 3 x 10- 9 M. The excitatory effects of NT persisted under blockade of synaptic transmission. The NT fragment neurotensin 8-13 and the NT analogue neuromedin N showed effects similar to those of NT, whereas the NT fragment neurotensin 1-8 had no effect on ACe neurons. Of 43 neurons in the septal nucleus, 8 cells (19%) and 3 cells (7%) showed excitatory and inhibitory responses, respectively, to NT. The results suggest that NT exerts a potent excitatory effect on ACe neurons through a direct action on specific receptors, in which NT may play a role in amygdala-relevant functions.

Original languageEnglish
Pages (from-to)135-141
Number of pages7
JournalBrain Research Bulletin
Volume40
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

Keywords

  • Amygdala
  • Brain slice
  • Central amygdaloid nucleus
  • Neuromedin N
  • Neurotensin
  • Neurotensin fragment
  • Septal nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lu, Y. F., Moriwaki, A., Hayashi, Y., Tomizawa, K., Itano, T., & Matsui, H. (1996). Effects of neurotensin on neurons in the rat central amygdaloid nucleus in vitro. Brain Research Bulletin, 40(2), 135-141. https://doi.org/10.1016/0361-9230(96)00044-5