Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy

Hiroshi Yamanari, Kengo Fukushima, Katsusi Miyaji, Mika Yamamoto, Satoshi Nagase, Fuyou Misunaga-Otsuka, Kazuaki Nakayama, Hiromi Matsubara, Tetsuro Emori, Tohru Ohe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods: Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exercise-induced myocardial ischemia were evaluated. Results: Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the TI-201 defect score (r = 0.61, P <0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exercise-induced myocardial ischemia than without exercise- induced myocardial ischemia (96 + 36, 72 ± 24 ms(1/2), P <0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms(1/2), P <0.0001). Conclusion: It is suggested that the degree of myocardial fibrosis influences the pre- exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalAnnals of Noninvasive Electrocardiology
Volume5
Issue number1
Publication statusPublished - 2000

Fingerprint

Hypertrophic Cardiomyopathy
Perfusion
Exercise
Myocardial Ischemia
Ventricular Tachycardia
Thallium
Exercise Test
Tachycardia
Fibrosis

Keywords

  • Exercise-induced myocardial ischemia
  • Hypertrophic cardiomyopathy
  • QT dispersion
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Yamanari, H., Fukushima, K., Miyaji, K., Yamamoto, M., Nagase, S., Misunaga-Otsuka, F., ... Ohe, T. (2000). Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy. Annals of Noninvasive Electrocardiology, 5(1), 60-67.

Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy. / Yamanari, Hiroshi; Fukushima, Kengo; Miyaji, Katsusi; Yamamoto, Mika; Nagase, Satoshi; Misunaga-Otsuka, Fuyou; Nakayama, Kazuaki; Matsubara, Hiromi; Emori, Tetsuro; Ohe, Tohru.

In: Annals of Noninvasive Electrocardiology, Vol. 5, No. 1, 2000, p. 60-67.

Research output: Contribution to journalArticle

Yamanari, H, Fukushima, K, Miyaji, K, Yamamoto, M, Nagase, S, Misunaga-Otsuka, F, Nakayama, K, Matsubara, H, Emori, T & Ohe, T 2000, 'Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy', Annals of Noninvasive Electrocardiology, vol. 5, no. 1, pp. 60-67.
Yamanari H, Fukushima K, Miyaji K, Yamamoto M, Nagase S, Misunaga-Otsuka F et al. Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy. Annals of Noninvasive Electrocardiology. 2000;5(1):60-67.
Yamanari, Hiroshi ; Fukushima, Kengo ; Miyaji, Katsusi ; Yamamoto, Mika ; Nagase, Satoshi ; Misunaga-Otsuka, Fuyou ; Nakayama, Kazuaki ; Matsubara, Hiromi ; Emori, Tetsuro ; Ohe, Tohru. / Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy. In: Annals of Noninvasive Electrocardiology. 2000 ; Vol. 5, No. 1. pp. 60-67.
@article{3986c718bbf641eba440a9ab08cd914f,
title = "Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy",
abstract = "Background: In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods: Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exercise-induced myocardial ischemia were evaluated. Results: Twelve patients (31{\%}) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the TI-201 defect score (r = 0.61, P <0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exercise-induced myocardial ischemia than without exercise- induced myocardial ischemia (96 + 36, 72 ± 24 ms(1/2), P <0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms(1/2), P <0.0001). Conclusion: It is suggested that the degree of myocardial fibrosis influences the pre- exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk.",
keywords = "Exercise-induced myocardial ischemia, Hypertrophic cardiomyopathy, QT dispersion, Ventricular tachycardia",
author = "Hiroshi Yamanari and Kengo Fukushima and Katsusi Miyaji and Mika Yamamoto and Satoshi Nagase and Fuyou Misunaga-Otsuka and Kazuaki Nakayama and Hiromi Matsubara and Tetsuro Emori and Tohru Ohe",
year = "2000",
language = "English",
volume = "5",
pages = "60--67",
journal = "Annals of Noninvasive Electrocardiology",
issn = "1082-720X",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Effects of myocardial perfusion on QT dispersion in patients with hypertrophic cardiomyopathy

AU - Yamanari, Hiroshi

AU - Fukushima, Kengo

AU - Miyaji, Katsusi

AU - Yamamoto, Mika

AU - Nagase, Satoshi

AU - Misunaga-Otsuka, Fuyou

AU - Nakayama, Kazuaki

AU - Matsubara, Hiromi

AU - Emori, Tetsuro

AU - Ohe, Tohru

PY - 2000

Y1 - 2000

N2 - Background: In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods: Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exercise-induced myocardial ischemia were evaluated. Results: Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the TI-201 defect score (r = 0.61, P <0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exercise-induced myocardial ischemia than without exercise- induced myocardial ischemia (96 + 36, 72 ± 24 ms(1/2), P <0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms(1/2), P <0.0001). Conclusion: It is suggested that the degree of myocardial fibrosis influences the pre- exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk.

AB - Background: In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods: Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exercise-induced myocardial ischemia were evaluated. Results: Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the TI-201 defect score (r = 0.61, P <0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exercise-induced myocardial ischemia than without exercise- induced myocardial ischemia (96 + 36, 72 ± 24 ms(1/2), P <0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms(1/2), P <0.0001). Conclusion: It is suggested that the degree of myocardial fibrosis influences the pre- exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk.

KW - Exercise-induced myocardial ischemia

KW - Hypertrophic cardiomyopathy

KW - QT dispersion

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=0034065067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034065067&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 60

EP - 67

JO - Annals of Noninvasive Electrocardiology

JF - Annals of Noninvasive Electrocardiology

SN - 1082-720X

IS - 1

ER -