Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats

Yasuhiro Kawakami, Yoshihisa Kitamura, Hiroaki Araki, Kouhei Kitagawa, Katsuya Suemaru, Kazuhiko Shibata, Yutaka Gomita

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We examined the influence of imipramine, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor, desipramine, a NA reuptake inhibitor, bupropion, a dopamine reuptake inhibitor, fluvoxamine, a selective 5-HT reuptake inhibitor, and mazindol, a catecholamine reuptake inhibitor, on a 5-HT 2A receptor-mediated behavior, (±)-1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI)-induced wet-dog shakes, in naive and adrenocorticotropic hormone (ACTH)-treated rats. Chronic administration of imipramine, desipramine and mazindol suppressed the number of wet-dog shakes in naive rats. Chronic ACTH (100 μg/rat, s.c.) treatment increased the number. Chronic administration of imipramine did not decrease the number of wet-dog shakes in ACTH-treated rats. On the other hand, desipramine and mazindol inhibited the increase in wet-dog shakes in ACTH-treated rats. Fluvoxamine and bupropion did not have any effect on the (±)-DOI-induced response in naive and ACTH-treated rats. NA reuptake inhibitors may improve the hyperfunction of 5-HT2A receptors induced by chronic ACTH treatment.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume81
Issue number1
DOIs
Publication statusPublished - May 2005

Fingerprint

Receptor, Serotonin, 5-HT2A
Adrenocorticotropic Hormone
Rats
Mazindol
Dogs
Desipramine
Imipramine
Fluvoxamine
Bupropion
Serotonin
Norepinephrine
Dopamine Uptake Inhibitors
Catecholamines

Keywords

  • 5-HT receptor
  • ACTH
  • Bupropion
  • Desipramine
  • DOI
  • Fluvoxamine
  • Imipramine
  • Mazindol
  • Wet-dog shake

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats. / Kawakami, Yasuhiro; Kitamura, Yoshihisa; Araki, Hiroaki; Kitagawa, Kouhei; Suemaru, Katsuya; Shibata, Kazuhiko; Gomita, Yutaka.

In: Pharmacology Biochemistry and Behavior, Vol. 81, No. 1, 05.2005, p. 65-70.

Research output: Contribution to journalArticle

Kawakami, Yasuhiro ; Kitamura, Yoshihisa ; Araki, Hiroaki ; Kitagawa, Kouhei ; Suemaru, Katsuya ; Shibata, Kazuhiko ; Gomita, Yutaka. / Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats. In: Pharmacology Biochemistry and Behavior. 2005 ; Vol. 81, No. 1. pp. 65-70.
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