Effects of monoamine reuptake inhibitors on wet-dog shakes mediated by 5-HT2A receptors in ACTH-treated rats

Yasuhiro Kawakami, Yoshihisa Kitamura, Hiroaki Araki, Kouhei Kitagawa, Katsuya Suemaru, Kazuhiko Shibata, Yutaka Gomita

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We examined the influence of imipramine, a serotonin (5-HT) and noradrenaline (NA) reuptake inhibitor, desipramine, a NA reuptake inhibitor, bupropion, a dopamine reuptake inhibitor, fluvoxamine, a selective 5-HT reuptake inhibitor, and mazindol, a catecholamine reuptake inhibitor, on a 5-HT 2A receptor-mediated behavior, (±)-1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane (DOI)-induced wet-dog shakes, in naive and adrenocorticotropic hormone (ACTH)-treated rats. Chronic administration of imipramine, desipramine and mazindol suppressed the number of wet-dog shakes in naive rats. Chronic ACTH (100 μg/rat, s.c.) treatment increased the number. Chronic administration of imipramine did not decrease the number of wet-dog shakes in ACTH-treated rats. On the other hand, desipramine and mazindol inhibited the increase in wet-dog shakes in ACTH-treated rats. Fluvoxamine and bupropion did not have any effect on the (±)-DOI-induced response in naive and ACTH-treated rats. NA reuptake inhibitors may improve the hyperfunction of 5-HT2A receptors induced by chronic ACTH treatment.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalPharmacology Biochemistry and Behavior
Issue number1
Publication statusPublished - May 2005


  • 5-HT receptor
  • ACTH
  • Bupropion
  • DOI
  • Desipramine
  • Fluvoxamine
  • Imipramine
  • Mazindol
  • Wet-dog shake

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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