Abstract
This study examines the influence of low dose X-ray irradiation on purine nucleotide metabolites such as adenosine, inosine, hypoxanthine, xanthine and uric acid, and hence generation of ATP-mediated energy in mouse splenocytes. It was found that, unlike high dose irradiation which promotes membrane damage, low dose irradiation enhances the ability to regulate the energy metabolisms as reflected by the increase in Na+, K+-ATPase activity and the adequate activation of the above salvage pathway. Namely, the levels of adenosine, inosine and uric acid significantly increased, while the levels of xanthine and hypoxanthine decreased significantly. Moreover, the cysteine level and Superoxide dismutase activity significantly increased at a dosage of 20 cGy.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Physiological Chemistry and Physics and Medical NMR |
| Volume | 29 |
| Issue number | 1 |
| Publication status | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biophysics
- Physiology
- Physiology (medical)
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Effects of Low Dose X-ray Irradiation on Purine Metabolism in Mouse Splenocytes. / Yamaoka, Kiyonori; Niki, Etsuo; Takahashi, Mareyuki; Iriyama, Keiji.
In: Physiological Chemistry and Physics and Medical NMR, Vol. 29, No. 1, 1997, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of Low Dose X-ray Irradiation on Purine Metabolism in Mouse Splenocytes
AU - Yamaoka, Kiyonori
AU - Niki, Etsuo
AU - Takahashi, Mareyuki
AU - Iriyama, Keiji
PY - 1997
Y1 - 1997
N2 - This study examines the influence of low dose X-ray irradiation on purine nucleotide metabolites such as adenosine, inosine, hypoxanthine, xanthine and uric acid, and hence generation of ATP-mediated energy in mouse splenocytes. It was found that, unlike high dose irradiation which promotes membrane damage, low dose irradiation enhances the ability to regulate the energy metabolisms as reflected by the increase in Na+, K+-ATPase activity and the adequate activation of the above salvage pathway. Namely, the levels of adenosine, inosine and uric acid significantly increased, while the levels of xanthine and hypoxanthine decreased significantly. Moreover, the cysteine level and Superoxide dismutase activity significantly increased at a dosage of 20 cGy.
AB - This study examines the influence of low dose X-ray irradiation on purine nucleotide metabolites such as adenosine, inosine, hypoxanthine, xanthine and uric acid, and hence generation of ATP-mediated energy in mouse splenocytes. It was found that, unlike high dose irradiation which promotes membrane damage, low dose irradiation enhances the ability to regulate the energy metabolisms as reflected by the increase in Na+, K+-ATPase activity and the adequate activation of the above salvage pathway. Namely, the levels of adenosine, inosine and uric acid significantly increased, while the levels of xanthine and hypoxanthine decreased significantly. Moreover, the cysteine level and Superoxide dismutase activity significantly increased at a dosage of 20 cGy.
UR - http://www.scopus.com/inward/record.url?scp=0030633951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030633951&partnerID=8YFLogxK
M3 - Article
C2 - 9353952
AN - SCOPUS:0030633951
VL - 29
SP - 1
EP - 9
JO - Physiological chemistry and physics
JF - Physiological chemistry and physics
SN - 0748-6642
IS - 1
ER -