Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats

Kiyonori Yamaoka, Rei Edamatsu, Takehiko Ito, Mori Akitane

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We previously found that low-dose X-ray irradiation or radon (weak α-ray) inhalation increases SOD activities and reduces lipid peroxide levels in various organs of 7-week-old rats or rabbit. In this study, we examined how the changes of SOD activity, lipid peroxide level, and membrane fluidity of the cerebral cortex in aged male Wistar rats (65 and 91 weeks old) were affected by low-dose X-ray irradiation (100 cGy or under) compared with those in 7-week-old rats, to elucidate the mechanism of aging inhibition. The following results were obtained: Although radiation sensitivity was observed to decreases with age, low-dose irradiation changed the Mn-SOD activity, lipid peroxide level, and membrane protein fluidity parameter of the cerebral cortex in the aged rats to be closer to those in the youth. These finding suggest that the increased SOD activity induced by low-dose irradiation enhances biomembrane functions, and that the decrease of lipid peroxide level enhances the membrane protein fluidity.

Original languageEnglish
Pages (from-to)529-534
Number of pages6
JournalFree Radical Biology and Medicine
Volume16
Issue number4
DOIs
Publication statusPublished - 1994

Fingerprint

Lipid Peroxides
Membrane Fluidity
Dosimetry
Fluidity
Rats
Brain
X-Rays
Irradiation
X rays
Cerebral Cortex
Membrane Proteins
Radon
Radiation Tolerance
Inhalation
Superoxide Dismutase
Wistar Rats
Aging of materials
Rabbits
Membranes
Radiation

Keywords

  • Aging
  • Biomembrane
  • Brain cortex
  • Decrease in lipid peroxide lebel
  • Free radicals
  • Increase in membrane protein fluidity
  • Increase in Mn-SOD activity
  • Low-dose irradiation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine(all)
  • Toxicology

Cite this

Effects of low-dose X-ray irradiation on biomembrane in brain cortex of aged rats. / Yamaoka, Kiyonori; Edamatsu, Rei; Ito, Takehiko; Akitane, Mori.

In: Free Radical Biology and Medicine, Vol. 16, No. 4, 1994, p. 529-534.

Research output: Contribution to journalArticle

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