Abstract
We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.
| Original language | English |
|---|---|
| Pages (from-to) | 161-165 |
| Number of pages | 5 |
| Journal | Physiological Chemistry and Physics and Medical NMR |
| Volume | 27 |
| Issue number | 3 |
| Publication status | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Biophysics
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Effects of low-dose gamma-irradiation to the chest regions on the blood pressure of spontaneous hypertensive rats. / Yamaoka, Kiyonori; Ishii, K.
In: Physiological Chemistry and Physics and Medical NMR, Vol. 27, No. 3, 1995, p. 161-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of low-dose gamma-irradiation to the chest regions on the blood pressure of spontaneous hypertensive rats.
AU - Yamaoka, Kiyonori
AU - Ishii, K.
PY - 1995
Y1 - 1995
N2 - We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.
AB - We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029433974&partnerID=8YFLogxK
M3 - Article
C2 - 8868576
AN - SCOPUS:0029433974
VL - 27
SP - 161
EP - 165
JO - Physiological chemistry and physics
JF - Physiological chemistry and physics
SN - 0748-6642
IS - 3
ER -