Effects of low-dose aspirin on endothelial function in hypertensive patients

H. Monobe, H. Yamanari, Kazufumi Nakamura, T. Ohe

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: It has been reported that administration of low-dose aspirin significantly reduces the frequency of major cardiovascular events in patients with hypertension and coronary artery disease. It is generally considered that the preventative effects of long-term aspirin administration on major cardiovascular events are due to the inhibition of platelet aggregation. Hypothesis: It is not known whether administration of low-dose aspirin restores endothelium-dependent vasodilatation, and this study was undertaken to prove or disprove this question in patients with hypertension. Methods: Flow-mediated endothelium-dependent dilatation and glyceryl trinitrate-induced endothelium-independent dilatation were investigated in 18 hypertensive patients and 10 normotensive control subjects. In the hypertensive patients, flow-mediated dilatation was investigated and cyclic guanosine monophosphate plasma (cGMP) was measured before and at 8 weeks after the administration of 162 mg of aspirin. Results: Flow-mediated dilatation before aspirin administration was more reduced in the hypertensive patients than in the control subjects (6.4 ± 2.0% vs. 11.3 ± 2.3%, p <0.0001). Glyceryl trinitrate-induced dilatation before aspirin administration was similar in hypertensive patients and control subjects. Flow-mediated dilatation after aspirin administration was improved compared with that before aspirin administration (10.4 ± 3.5% vs. 6.4 ± 2.0%, p <0.0004). The cGMP product after aspirin administration was significantly higher than that before aspirin administration. Conclusions: Administration of low-dose aspirin may restore the endothelium-dependent vasodilatation in hypertensive patients. Furthermore, increased nitric oxide production may play a partial role in the improvement in endothelial function induced by administration of low-dose aspirin.

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalClinical Cardiology
Volume24
Issue number11
Publication statusPublished - 2001

Fingerprint

Aspirin
Dilatation
Endothelium
Cyclic GMP
Nitroglycerin
Vasodilation
Hypertension
Platelet Aggregation
Coronary Artery Disease
Nitric Oxide

Keywords

  • Aspirin
  • Cyclic guanosine monophosphate plasma
  • Endothelial function
  • Hypertension
  • Nitric oxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of low-dose aspirin on endothelial function in hypertensive patients. / Monobe, H.; Yamanari, H.; Nakamura, Kazufumi; Ohe, T.

In: Clinical Cardiology, Vol. 24, No. 11, 2001, p. 705-709.

Research output: Contribution to journalArticle

Monobe, H, Yamanari, H, Nakamura, K & Ohe, T 2001, 'Effects of low-dose aspirin on endothelial function in hypertensive patients', Clinical Cardiology, vol. 24, no. 11, pp. 705-709.
Monobe, H. ; Yamanari, H. ; Nakamura, Kazufumi ; Ohe, T. / Effects of low-dose aspirin on endothelial function in hypertensive patients. In: Clinical Cardiology. 2001 ; Vol. 24, No. 11. pp. 705-709.
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