Effects of long-term treatment with calcium antagonists on periarterial nerve function in the mesenteric artery of spontaneous hypertensive rats

A. Nakatsuma, H. Kawasaki, Y. Kurosaki, K. Futagami, H. Araki, Y. Gomita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of long-term treatment with dihydropyridine calcium antagonists (amlodipine, pranidipine, nicardipine) on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat (SHR). Male 8-week-old SHR received amlodipine (0.01% and 0.02%) and nicardipine (0.1%) in drinking water and pranidipine (0.0035% and 0.035%) in rat chow for 7 weeks. Mean blood pressure in SHR was significantly lowered by long-term treatment with each calcium antagonist. In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation (PNS; 4, 8 and 12 Hz) was significantly smaller than that in non-treated SHR. The PNS (8 Hz)-evoked norepinephrine (NE) overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine-treatment significantly enhanced the overflow of NE. In preparations with active tone produced by methoxamine and guanethidine, the PNS-induced vasolidation mediated by calcitonin gene-related peptide (CGRP)-containing (CGRPergic) vasodilator nerves was not affected by these drugs. These results suggest that long-tern treatment of SHR with long-acting drugs, amlodipine and pranidipine, reduces sympathetic adrenergic nerve function but calcium antagonists have no effect on CGRPergic nerve function.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalJapanese Journal of Pharmacology
Volume84
Issue number2
DOIs
Publication statusPublished - Nov 25 2000

Keywords

  • Adrenergic vasoconstrictor nerve
  • Calcium antagonist
  • Calcium gene-related peptide-containing vasodilator nerve
  • Mesenteric artery
  • Spontaneously hypertensive rat

ASJC Scopus subject areas

  • Pharmacology

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