Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk

A case--control study in Japanese women

Taeko Mizoo, Naruto Taira, Keiko Nishiyama, Tomohiro Nogami, Takayuki Iwamoto, Takayuki Motoki, Tadahiko Shien, Junji Matsuoka, Hiroyoshi Doihara, Setsuko Ishihara, Hiroshi Kawai, Kensuke Kawasaki, Youichi Ishibe, Yutaka Ogasawara, Yoshifumi Komoike, Shinichiro Miyoshi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk. Methods: A case--control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression analyses. Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95% CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers. Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.

Original languageEnglish
Pages (from-to)565
Number of pages1
JournalBMC Cancer
DOIs
Publication statusAccepted/In press - Dec 1 2013

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Single Nucleotide Polymorphism
Case-Control Studies
Life Style
Breast Neoplasms
Alleles
Odds Ratio
Exercise
Leisure Activities
Smoking
Confidence Intervals
Agaricales
Genome-Wide Association Study
Coffee
Genetic Association Studies
Tea
Body Composition
Vegetables
Meat
Population
Multivariate Analysis

ASJC Scopus subject areas

  • Genetics
  • Cancer Research
  • Oncology

Cite this

Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk : A case--control study in Japanese women. / Mizoo, Taeko; Taira, Naruto; Nishiyama, Keiko; Nogami, Tomohiro; Iwamoto, Takayuki; Motoki, Takayuki; Shien, Tadahiko; Matsuoka, Junji; Doihara, Hiroyoshi; Ishihara, Setsuko; Kawai, Hiroshi; Kawasaki, Kensuke; Ishibe, Youichi; Ogasawara, Yutaka; Komoike, Yoshifumi; Miyoshi, Shinichiro.

In: BMC Cancer, 01.12.2013, p. 565.

Research output: Contribution to journalArticle

Mizoo, T, Taira, N, Nishiyama, K, Nogami, T, Iwamoto, T, Motoki, T, Shien, T, Matsuoka, J, Doihara, H, Ishihara, S, Kawai, H, Kawasaki, K, Ishibe, Y, Ogasawara, Y, Komoike, Y & Miyoshi, S 2013, 'Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: A case--control study in Japanese women', BMC Cancer, pp. 565. https://doi.org/10.1186/1471-2407-13-565
Mizoo, Taeko ; Taira, Naruto ; Nishiyama, Keiko ; Nogami, Tomohiro ; Iwamoto, Takayuki ; Motoki, Takayuki ; Shien, Tadahiko ; Matsuoka, Junji ; Doihara, Hiroyoshi ; Ishihara, Setsuko ; Kawai, Hiroshi ; Kawasaki, Kensuke ; Ishibe, Youichi ; Ogasawara, Yutaka ; Komoike, Yoshifumi ; Miyoshi, Shinichiro. / Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk : A case--control study in Japanese women. In: BMC Cancer. 2013 ; pp. 565.
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abstract = "Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk. Methods: A case--control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95{\%} confidence intervals (95{\%} CI) were estimated from logistic regression analyses. Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95{\%} CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers. Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.",
author = "Taeko Mizoo and Naruto Taira and Keiko Nishiyama and Tomohiro Nogami and Takayuki Iwamoto and Takayuki Motoki and Tadahiko Shien and Junji Matsuoka and Hiroyoshi Doihara and Setsuko Ishihara and Hiroshi Kawai and Kensuke Kawasaki and Youichi Ishibe and Yutaka Ogasawara and Yoshifumi Komoike and Shinichiro Miyoshi",
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T1 - Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk

T2 - A case--control study in Japanese women

AU - Mizoo, Taeko

AU - Taira, Naruto

AU - Nishiyama, Keiko

AU - Nogami, Tomohiro

AU - Iwamoto, Takayuki

AU - Motoki, Takayuki

AU - Shien, Tadahiko

AU - Matsuoka, Junji

AU - Doihara, Hiroyoshi

AU - Ishihara, Setsuko

AU - Kawai, Hiroshi

AU - Kawasaki, Kensuke

AU - Ishibe, Youichi

AU - Ogasawara, Yutaka

AU - Komoike, Yoshifumi

AU - Miyoshi, Shinichiro

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N2 - Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk. Methods: A case--control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression analyses. Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95% CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers. Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.

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