Effects of levocabastine on lipid mediator release from guinea pig lung fragments

Yukio Sugimoto; Yoshinori Iba; Keisuke Ishizawa; Genzo Suzuki; Chiaki Kamei

Effects of levocabastine on lipid mediator release from guinea pig lung fragments

Yukio Sugimoto, Yoshinori Iba, Keisuke Ishizawa, Genzo Suzuki, Chiaki Kamei

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of levocabastine, a novel histamine H₁-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C₄ from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10^-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E₄ or thromoboxane B₂. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C₄ release.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Acta medica Okayama
Volume	53
Issue number	6
Publication status	Published - Dec 1 1999

Keywords

Guinea pig
Levocabastine
Lipid mediator
Lung fragment

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Effects of levocabastine on lipid mediator release from guinea pig lung fragments",

abstract = "The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.",

keywords = "Guinea pig, Levocabastine, Lipid mediator, Lung fragment",

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T1 - Effects of levocabastine on lipid mediator release from guinea pig lung fragments

AU - Sugimoto, Yukio

AU - Iba, Yoshinori

AU - Ishizawa, Keisuke

AU - Suzuki, Genzo

AU - Kamei, Chiaki

PY - 1999/12/1

Y1 - 1999/12/1

N2 - The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.

AB - The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.

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KW - Levocabastine

KW - Lipid mediator

KW - Lung fragment

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