Effects of levocabastine on lipid mediator release from guinea pig lung fragments

Yukio Sugimoto, Yoshinori Iba, Keisuke Ishizawa, Genzo Suzuki, Chiaki Kamei

Research output: Contribution to journalArticle

Abstract

The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalActa medica Okayama
Volume53
Issue number6
Publication statusPublished - Dec 1 1999

Keywords

  • Guinea pig
  • Levocabastine
  • Lipid mediator
  • Lung fragment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Sugimoto, Y., Iba, Y., Ishizawa, K., Suzuki, G., & Kamei, C. (1999). Effects of levocabastine on lipid mediator release from guinea pig lung fragments. Acta medica Okayama, 53(6), 271-274.