Effects of Lecithinized SOD on Contusion Injury in Rats

M. Yunoki; Y. Noguchi; S. Nishio; Y. Ono; M. Kawauchi; S. Asai; T. Ohmoto; M. Asanuma; N. Ogawa

doi:10.1007/978-3-7091-6837-0_56

Effects of Lecithinized SOD on Contusion Injury in Rats

M. Yunoki, Y. Noguchi, S. Nishio, Y. Ono, M. Kawauchi, S. Asai, T. Ohmoto, M. Asanuma, N. Ogawa

Research output: Contribution to journal › Article › peer-review

Abstract

To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.

Original language	English
Pages (from-to)	182-184
Number of pages	3
Journal	Acta Neurochirurgica, Supplement
Volume	1997
Issue number	70
DOIs	https://doi.org/10.1007/978-3-7091-6837-0_56
Publication status	Published - Jan 1 1997

Keywords

Contusion
Free radicals
Superoxide dismutase (SOD)

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1007/978-3-7091-6837-0_56

Cite this

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title = "Effects of Lecithinized SOD on Contusion Injury in Rats",

abstract = "To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.",

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T1 - Effects of Lecithinized SOD on Contusion Injury in Rats

AU - Yunoki, M.

AU - Noguchi, Y.

AU - Nishio, S.

AU - Ono, Y.

AU - Kawauchi, M.

AU - Asai, S.

AU - Ohmoto, T.

AU - Asanuma, M.

AU - Ogawa, N.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.

AB - To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.

KW - Contusion

KW - Free radicals

KW - Superoxide dismutase (SOD)

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Effects of Lecithinized SOD on Contusion Injury in Rats

Abstract

Keywords

ASJC Scopus subject areas

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