Effects of Lecithinized SOD on Contusion Injury in Rats

M. Yunoki, Y. Noguchi, S. Nishio, Y. Ono, M. Kawauchi, S. Asai, T. Ohmoto, M. Asanuma, N. Ogawa

Research output: Contribution to journalArticle

Abstract

To analyze the effect of lecithinized superoxide dismutase (SOD) on superoxide accumulation after traumatic injury, the expression of Cu,Zn-SOD mRNA was examined after contusion in rat using Northern blotting. As determined by specific gravity, lecithinized SOD decreased brain edema. The expression of Cu,Zn-SOD mRNA increased at the core, peripheral and contralateral hemisphere of injury. These increases were then suppressed by lecithinized SOD. Our results support the hypothesis that superoxide may play an important role in edema formation after contusion, and that lecithinized SOD appears to prevent brain edema through a protective effect against superoxide injury.

Original languageEnglish
Pages (from-to)182-184
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume1997
Issue number70
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • Contusion
  • Free radicals
  • Superoxide dismutase (SOD)

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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